多器官功能障碍综合征血浆游离氨基酸代谢的研究  

A STUDY ON PLASMA FREE AMINO ACID MEABOLISM IN MULTIPLE ORGAN DYS一FUNCTION SNYDROME

作　　者：黎君友[1] 胡森[1] 吕艺[1] 晋桦[1] 孙世荣[1] 薛立波 董元林[1] 周宝桐[1] 盛志勇[1] 

机构地区：[1]解放军第304医院

出　　处：《解放军医学杂志》1996年第1期27-29,共3页Medical Journal of Chinese People's Liberation Army

基　　金：军队医药卫生"八五"重点攻关课题

摘　　要：分析了犬肠缺血、兔单相速发ＭＯＤＳ模型，和山羊双相迟发ＭＯＤＳ模型以及烧伤合并ＭＯＤＳ病人的血浆游离氨基酸的变化。结果表明，ＭＯＤＳ的发病过程中，ＢＣＡＡ／ＡＡＡ值显著降低；Ｐｈｅ／Ｔｙｒ值显著升高。ＢＣＡＡ／ＡＡＡ越低，Ｐｈｅ／Ｔｙｒ越高，与ＭＯＤＳ的发生密切相关。提示严重蛋白质代谢紊乱可能是促发ＭＯＤＳ的原因之一；动态观察ＢＣＡＡ／ＡＡＡ和Ｐｈｅ／Ｔｙｒ比值的变化，对ＭＯＤＳ的早期诊断和防治可能有积极意义。Changes in plasma free amino acid both in burned patients with MODS and in different models of MODS were studied in dogs,rabbits and goats。 The resuIts indicated that ratios of branched-chain amino acids/aro matic amino acids(BCAA/AAA) were significantly decreased while ratios of Phe/Tyr were significantly increased both in patients and in animals in development of MODS。 Correlation coefficient were found between these ratios and the incidence of MODS. It suggested that disturbances in protein metabolism was one of the leading causes in MODS. Dynamic determination of ratios of BCAA/AAA and Phe/Tyr might be helpful in early diagnosis of MODS.

关 键 词：多器官衰竭 MODS 血浆 氨基酸 烧伤 

分 类 号：R644.06[医药卫生—外科学] R59[医药卫生—临床医学]