高血压病患者血清脂蛋白、载脂蛋白与胰岛素的关系  

The Correlation Between Serumal Lipoproteins,Apolipoproteins and Insulin Levels in Primary Hypertensive Patients

作　　者：李自成[1] 曹茂银[1] 王瑞英[1] 田翠姣 周毅 黄文增[1] 张才仁 

机构地区：[1]湖北医科大学附二医院心内科,武汉430071

出　　处：《湖北医科大学学报》1996年第1期40-43,共4页

基　　金：湖北省卫生厅资助课题

摘　　要：通过检测41例高血压病患者和27例正常对照者血清脂质、脂蛋白、载脂蛋白(Apo)、葡萄糖(G)及胰岛索(I)含量。结果表明:与正常对照者比较,高血压病患者血清甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-CH)、ApoB、I 及 I/G 比值均显著增加,高密度脂蛋白胆固醇(HDL-CH)、HDL_2-CH、ApoAI及 ApoAI/ApoB 比值均显著降低。相关性分析显示,高血压病 I 与 TG 和 ApoB 均呈正相关,与 HDL_2-CH 和 ApoAI/ApoB 均呈负相关;I/G 比值与血脂指标的相关性除同 I 外,还与 LDL-CH 呈正相关,与HDL-CH 和 ApoAI 均呈负相关。结果提示高血压病患者血脂代谢异常与胰岛素抵抗密切相关。Serumal lipids,lipoproteins,apolipoproteins,glucose(G) and insulin (I) levels were mea- sured in 41 primary hypertensive patients and 27 normal persons.The results showed that com- pared with the normal persons,serumal TG,LDL-CH,AproB,I and the ratio I/G were singifi- eantly increased and HDL-CH,HDL_2-CH,ApoAI and the ratio of ApoAI/ApoB were significant- ly decreased,in primary hypertensive patients.The correlative analysis suggested that insulin have a positive correlation with TG and ApoB,and a negative correlation with HDL_2-CH and ApoAI/ApoB (all P<0.05,0.01) and besides the same correlation between insulin and blood lipids indices,the ratio of I/G was positively correlated to LDL-CH andnegatively correlaled to HDL-CH and ApoAI (all P<0.05,0.01).Therefore,dyslipidemia is closer correlative with in- sulin resistance in primary hypertensive patients.

关 键 词：高血压 病理学 胰岛素 载体蛋白 脂蛋白 

分 类 号：R544.102[医药卫生—心血管疾病]