低度乙醇对胃粘膜血流量的影响及其适应性细胞保护作用  

Effect of Ethanol on Gastric Mucosal Blood Flow and Cytoprotection

作　　者：黄梅芳[1] 邓长生[1] 周燕[1] 

机构地区：[1]湖北医科大学附二医院消化内科,武汉430071

出　　处：《湖北医科大学学报》1996年第1期43-45,共3页

摘　　要：选用低度乙醇作为弱刺激因子,观察其对胃粘膜血流量(GMBF)及胃粘膜损伤的影响,探讨GMBF 与适应性细胞保护作用的关系。结果显示:10%、20%乙醇使大鼠 GMBF 增加,不引起胃粘膜损伤;40%及无水乙醇使大鼠 GMBF 减少,并产生明显的胃粘膜损伤;10%、20%的乙醇预先灌胃能减轻无水乙醇所致的胃粘膜损伤,部分抵抗无水乙醇所至的 GMBF 减少。经相关分析,GMBF 与损伤指数呈显著负相关。结果提示低度乙醇能增加 GMBF,具有适应性细胞保护作用。The effects of ethanol on GMBF and eytoprotection were studied in rats.The gastric lesions were produced by oral 100 precent ethanol.The GMBF was produced by organ reflectance spec- trophotometry.The results showed that oral 1 ml of 10 precent and 20 precent ethanol increased GMBF and did not produced any gastric lesions.Oral 1 ml of 100 precent ethanol produced gas- tric mueosal lesions and significantly decreased GMBF.Oral 10 preterit and 20 precent ethanol can reversed the effect of 100 preeent ethanol induced decrease of GMBF and gastric mueosal le- sions.The results suggested 10 precent and 20 precent ethanol have the effects of increasing GMBF and cytoprotection.

关 键 词：胃粘膜 血液供给 药理学 乙醇 细胞保护作用 

分 类 号：R979.7[医药卫生—药品]