血吸虫病蛊胀模型之研究  

STUDY ON TYMPANITES MODEL OF SCHISTOSOMIASIS

作　　者：郭振球 杨运高 黄文通 

机构地区：[1]中医诊断研究所,湖南省寄生虫病研究所

出　　处：《湖南中医学院学报》1996年第1期35-39,共5页Journal of Hunan College of Traditional Chinese Medicine

基　　金：国家自然科学基金

摘　　要：用ＢＡＬＢ／Ｃ纯系小自鼠感染血吸虫尾蚴后３１天，找样解剖，了解尾蚴雌雄合抱。第七周用吡喹酮全剂全杀虫。制成模型，腹部胀大，肘脾重量显著高于正常组。肝脾呈紫色，包膜充血，肝脏表面布满灰白色粟粒样结节，脾髓索内有嗜酸性细胞浸润。肝脏汇管区有虫卵结节及胶原纤维增生，肝组织淋巴细胞，单核细胞及嗜酸性白细胞浸润”。模型组ＰＯＸ、ＡＮＡＥ、ＡＫＰ含量下降；ＭＡＯ、ＡＣＰ含量升高。形成了类似中医学的虫、瘀、水互结，虫、瘀为主的蛊胀病理模型。After 31 days,BALB/Cmice were infected schistosoma miracidium andthe miracidium were monoecious,In 7thweek,themodel was madeof which the abdomenwas enlarged,and the liver arid splen were mucli wigl1ter than the normal group. In the modelgroup POX,ANAE and AKP content lowered and MAO arid ACP content increased,which-formed a pathologial model which was similar to the tympanites of TCM.

关 键 词：血吸虫病 蛊胀 疾病模型 

分 类 号：R259.322.1[医药卫生—中西医结合]