电针对慢性应激抑郁模型大鼠行为改变的影响  

Effect of Electroacupuncture on Behavioral Changes of Chronic Unpredictable Stre ss-induced Depression Model Rats

作　　者：刘琼[1,2] 俞瑾[1] 毛应启梁[1] 宋明娟[1] 米文丽[1] 吴根诚[1] 

机构地区：[1]复旦大学上海医学院中西医结合系,针刺原理研究所 [2]新乡医学院生化教研室,河南453003

出　　处：《上海针灸杂志》2005年第11期41-43,共3页Shanghai Journal of Acupuncture and Moxibustion

基　　金：国家自然科学基金(30371798);教育部博士点科研基金(20020246043)

摘　　要：目的观察电针的抗抑郁作用。方法将32只SD雄性大鼠随机分为正常组、抑郁模型组、抑郁模型加电针组和抑郁模型加氯丙咪嗪组,每组8只。采用慢性不可预见性应激刺激诱导大鼠抑郁模型,于实验前1天和实验第14、28天用敞箱实验法(Open-fieldtest)测定大鼠行为,观察电针对模型大鼠行为改变的影响。结果与正常组相比,抑郁模型组大鼠的水平穿越格数、直立次数和体重增长数均减少;与抑郁模型组相比,电针和氯丙咪嗪能明显增加大鼠的水平穿越格数和直立次数,而对体重增长的减少没有明显改变。结论电针能明显改善抑郁大鼠的抑郁状态,具有抗抑郁作用。Objective To observe the antidepressant effect of electrocupuncture （EA） in stress-induced depression model rat. Method Thirty-two SD male rats were randomly divided into four groups as follows ： normal, depression model, depression model plus EA, depression model plus chlorimipramine. By using the open-field test, the effects of EA were observed on the day before stimulation, and the 14th, 28th day during experiment. Results Depression model rats exhibited reduced crossing and rearing and the in- crease of body weight, as compared with the normal group. Compared with the depression model group, EA and chlorimipramine could significantly improve the number of crossing and rearing. However, the increase of body weight had no significant difference among depression model group, depression model plus EA group and depression model plus chlorimipramine group. Conclusion EA can improve behavior of depression model rats and possess an antidepressant effect.

关 键 词：电针 慢性刺激 抑郁症 氯丙咪嗪 

分 类 号：R246.6[医药卫生—针灸推拿学]