利用基质抑制效应检测小质量的气溶胶粒子  

Detecting Small Molecules of Aerosol Particles Using Matrix Suppression Effect

作　　者：周留柱 朱元[1] 郭晓勇[1] 赵文武[1] 郑海洋[1] 顾学军[1] 方黎[1] 张为俊[1] 

机构地区：[1]中国科学院安徽光学精密机械研究所环境光谱学实验室

出　　处：《分析化学》2005年第11期1551-1554,共4页Chinese Journal of Analytical Chemistry

基　　金：中国科学院创新重要方向性基金资助项目(No.KJCX2-SW-H08)

摘　　要：研究了气溶胶粒子的基质辅助激光解吸附电离质谱,在基质对分析物的摩尔比较高时,同时出现了基质和分析物离子峰;在基质对分析物的摩尔比低于5∶1时,出现了基质抑制效应。基质抑制效应可以产生高质量的质谱,即:质谱中分析物信号较强,基质信号很弱或者消失。因此,利用基质抑制效应,可以检测低分子量的分析物。The matrix-assisted laser desorption/ionization （MALDI）mass spectra of aerosol were investigated The areosol particles containing matrix and analyte, generated in Devilbiss 40^# nebulizer, were collected by a glass bottle and were derected into the aeroiol time-of-flight mass spectrometry （ATQFMS）. When the mole ratio of matrix -to-analyte was higher,both the ion peaks of matrix and analyte were observed. When the ratio was less than 5：1, matrix suppression effect （MSE） appeared. It can lead to high-quality MALDI mass spectra as strong analyte signals and weak or negligible matrix background peaks. Therefore, the MSE can be aoolied to the measurement of low molecular weight analyte.

关 键 词：气溶胶飞行时间质谱仪 基质辅助激光解吸附电离 基质抑制效应 气溶胶粒子 抑制效应 基质 质量 检测 电离质谱 低分子量 

分 类 号：O657.63[理学—分析化学] O648.1[理学—化学]