161例缺氧缺血性脑病新生儿听损伤特征分析  

Characteristic analysis of hearing loss in 161 neonates with HIE

作　　者：陈平[1] 唐安洲[1] 孙华[2] 郑明华[1] 黄东红[1] 

机构地区：[1]广西医科大学第一附属医院耳鼻喉科,广西南宁530021 [2]广西医科大学第一附属医院神经内科

出　　处：《临床儿科杂志》2005年第8期551-553,共3页Journal of Clinical Pediatrics

摘　　要：目的探讨缺氧缺血性脑病(HIE)新生儿及其与高胆红素血症或极低出生体重儿(VLBW)分别或同时存在时的听力损伤特点,为早期干预治疗提供依据。方法将161例(322耳)新生儿分为单纯HIE组、HIE+高胆红素血症组、HIE+VLBW组、HIE+VLBW+高胆红素血症4组,对每组患儿予听性脑干诱发电位(ABR)检测。结果HIE新生儿ABR总反应阈为(53.57±18.46)dBnHL,总异常率为43.48%,当HIE与高胆红素血症、VLBW3种高危因素同时并存时,其异常发生率、重度异常发生率、平均反应阈均较单纯HIE显著提高。结论新生儿HIE与高胆红素血症、VLBW等高危因素分别或同时并存时,听损伤的机率相应增加,听损伤的程度也随之加重。此类患儿更应及早干预、重点随访。Objective To evaluate the characteristic pattern of hearing impairment in neonates with hypoxic-ischemic encepholopathy（HIE）and with either hyperbilirubinemia or very low birth weight（VLBW）, to provide the evidence of early intervention. Methods A total of 161 HIE neonates（322 ears）were divided into four groups： the neonates only with HIE, the neonates with HIE and hyperbilirubinemia, the neonates with HIE and very low-birth weight（VLBW）, and the neonates with HIE, hyperbilirubinemia and VLBW, Auditory brainstem response（ABR） analysis was carried out to all the patients. Results The hearing threshold of ABR in HIE neonates was（53.57±18.46）dBnHL,and the overall abnormal rate was 43.48%. The hearing threshold of ABR elevated and the abnormal rate was much higher in HIE neonates with either hyperbilirubinemia or VLBW. Conclusions The frequency of hearing impairment increased in the patients with the risk factors such as HIE, hyperbilirubinemia and VLBW concurrently and the severity of the hearing impairment was also much serious. It is necessary that more attention should be paid to these neonates for close follow-up and early intervention.

关 键 词：听性脑干诱发电位 缺氧缺血性脑病 新生儿 高胆红素血症 极低出生体重儿 

分 类 号：R722.1[医药卫生—儿科]