盐酸去氢骆驼蓬碱血浆蛋白结合率的测定  

Determination of plasma protein binding rate of harmine hydrochloride

作　　者：王长虹[1] 邹小广 孙殿甲[1] 王峥涛 

机构地区：[1]新疆医科大学药学院,新疆乌鲁木齐830054 [2]新疆喀什地区第二人民医院,新疆喀什844000 [3]上海医药大学中药研究所上海中药标准化研究中心,上海201203

出　　处：《中国医院药学杂志》2005年第2期99-101,共3页Chinese Journal of Hospital Pharmacy

基　　金：国家科技攻关资助项目(编号:2001BA754C)

摘　　要：　目的:测定盐酸去氢骆驼蓬碱的血浆蛋白结合率。方法:采用超滤法和高效液相色谱法对盐酸去氢骆驼蓬碱的血浆蛋白结合率进行测定。结果:盐酸去氢骆驼蓬碱与小牛血清白蛋白、人血清白蛋白和正常人血浆的蛋白结合率分别为(74.6±9.8)%、(69.1±8.7)%、(87.1±5.3)%。结论:盐酸去氢骆驼蓬碱与血浆蛋白具有中等强度的结合。OBJECTIVE To study the plasma protein binding rate of harmine hydrochloride. METHODS The ultrafiltration was employed to determine the plasma protein binding rate of harmine hydrochloride. The plasma concentrations of harmine hydrochloride were measured by RP-HPLC. RESULTS The plasma protein binding rate of harmine hydrochloride with BSA, HSA and normal human plasma were （74.6±9.8）%,（69.1 ±8.7）% and （87.1±5.3）%, respectively. CONCLUSION The binding rate of harmine hydrochloride with plasma protein is middling strength.

关 键 词：盐酸去氢骆驼蓬碱 血浆蛋白结合率 超滤法 

分 类 号：R969.1[医药卫生—药理学]