不同阶段海洛因成瘾大鼠脑内单胺递质的变化  

Changes of monoamine transmitters of different periods in the brain of heroin dependence-rats

作　　者：韦世秀[1] 蒙子卿[1] 叶峻[1] 蒋春华[1] 

机构地区：[1]广西医科大学医学科学实验中心,广西南宁530021

出　　处：《中国医院药学杂志》2005年第5期396-398,共3页Chinese Journal of Hospital Pharmacy

基　　金：广西壮族自治区科学研究与开发计划项目(编号:桂科攻0015050)

摘　　要：目的观察不同阶段海洛因成瘾大鼠脑内去甲肾上腺素(NE)、多巴胺(DA)、5羟色胺(5HT)及5羟吲哚乙酸(5HIAA)的变化。方法模拟人类吸毒成瘾、治疗;复吸成瘾,再治疗周而复始的模式。按递增法给大鼠染毒,造成动物海洛因成瘾。剖取不同阶段的鼠脑,以荧光分光光度法检测单胺类递质含量。结果各阶段海洛因成瘾鼠脑单胺类递质含量明显增高,5HT代谢物亦明显增高。α银环蛇毒素和美沙酮等治疗均能显著降低单胺递质。结论海洛因成瘾的大鼠,不同阶段的脑内单胺递质明显升高,两种治疗方案均可显著降低单胺类递质、缓解戒断症状。OBJECTIVE To study the changes of NE,DA, 5 HT and 5-HIAA at different periods in the brain of heroin depend ence-rats. METHODS The drug dependence-animals were made by injecting heroin in gradual increasing dosage and the relapse models of heroin addiction were established by a similar way to the human being drug abusers, i. e drug-taking dependence, treatment;relapse dependence, re-treatment again. The rat brain specimen were obtained from different periods and the contents of monoamine transmitters were detected by fluorescence photometric method. RESULTS The contents of monoamine transmitters were increased prominently at different periods in the brain of heroin dependentce-rats, the metabolic products of 5 HT were also increased. Monoamine transmitters were decreased after treatment with both α-bungarotoxin and methadone therapy. CONCLUSION Monoamine transmitters were increased significantly at different periods in the brain of heroin dependence-rats, α-bungarotoxin and methadone therapy could inhibit the increase of monoamine transmitters and relieve withdrawal symptoms.

关 键 词：海洛因 依赖性 单胺递质 美沙酮 Α-银环蛇毒素 

分 类 号：R964[医药卫生—药理学] R971[医药卫生—药学]