尿微量系列蛋白测定对肥胖相关肾病早期诊断的意义  

Clinical Significance of Urinary Microprotein Examination on Early Diagnosis of Obesity - Related Glomerulopathy in Children

作　　者：方林钧[1] 何威逊[1] 

机构地区：[1]上海交通大学附属儿童医院,上海200040

出　　处：《实用儿科临床杂志》2005年第6期514-515,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨尿微量系列蛋白检测对早期发现单纯性肥胖患儿肾损害的临床意义。方法用ELISA方法对40例单纯性肥胖患儿尿微量系列蛋白进行检测,并对50例健康儿童测尿微量系列蛋白作为对照。同时测血脂及作肾功能检查。结果单纯性肥胖患儿40例尿微量系列蛋白检测发现8例异常,5例清蛋白(Alb)增高,其中1例转铁蛋白(TRF)、尿视黄醇结合蛋白(RBP)同时增高,3例TRF增高。对其中1例行肾组织活检,结果提示异常。正常儿童50例尿微量系列蛋白检测均正常。结论尿微量系列蛋白检测可作为早期诊断儿童相关肾病的敏感指标。Objective To study the clinical significance of urinary microproteins examination on early diagnosis of kidney damage of children with obesity. Method Urinary microproteins were tested in 40 obese children by enzyme - linked immunosorbent assay and 50 healthy children as controls. Results Urinary microprotein examination were abnormal in 8 obese children. Albumin in 5 cases increased ,and transferrin（TRF） with retinol - binding protein in 1 case increased meanwhile. TRF in 3 cases increased. One case was abnormal by kidney biopsy. Conclusion Urinary microprotein examination was the sensitive index in early diagnosis of obesity - related glomerulopathy in children.

关 键 词：儿童 肥胖症 肾损害 尿微量蛋白 

分 类 号：R446.6[医药卫生—诊断学]