减肥对单纯性肥胖儿童糖耐量及胰岛素分泌功能的影响  

Influence of Weight - Lost on Glucose Intolerance Test and Insulin Secretion in Obese Children

作　　者：李洪玲[1] 罗小平[1] 王慕逖[1] 

机构地区：[1]华中科技大学同济医学院,武汉430030

出　　处：《实用儿科临床杂志》2005年第6期520-521,共2页Journal of Applied Clinical Pediatrics

基　　金：河南省科技厅科技攻关项目资助(0224630064)

摘　　要：目的探索单纯性肥胖儿童糖耐量减低(IGT)的干预方法。方法测定14例单纯性肥胖儿童经日服葡萄糖耐量实验(OGTT),诊断为IGT,男10例,女4例;年龄8-15岁;体质量(57.7-114.0)kg,体质量指数(BMI)(30.18±1.71)。给予中医循经推拿和行为矫正及饮食、运动调整综合减重治疗2个月。结果14例IGT肥胖儿童减肥治疗2个月后9例OGTT恢复正常,体质量下降至(49-95)kg;BMI下降至(25.30±1.35)kg;治疗后空腹胰岛素、餐后2 h胰岛素、餐后2 h血糖[(14.23 ±2.35)mIU/L、(47.20±10.26)mIU/L、(5.63±0.91)mmol/L]较治疗前[(32.54±7.13)mIU/L、(164.53±33.60)mIU/ L、(8.75±1.09)mmol/L]明显下降(P<0.05,<0.01,<0.05);空腹血糖(4.80±0.52)mmol/L和治疗前(5.36±1.59) mmol/L比较无明显差异(P>0.05)。结论减肥是干预单纯性肥胖儿童IGT、改善胰岛素抵抗及预防2型糖尿病的最好方法。Objective To observe the influence of weight - lost therapy on obese children with impaired gluccese tolerance（IGT）, insulin resistance. Methods Fasting, post - prandail 2 hours blood glucose and insulin were measured in 14 obese children （age 8 - 15 years） with IGT before and after two- month weight - lost therapy, Glucose were measured with enzymeoxidize assay,and insulin were measured with radio- immunity assay（RIA）. Results Among 14 obese children with IGT. after two- month weight - lost the-rapy, there were 9 children becoming normal OGTT. There were significantly lower in the concentration of fasting insulin and post - prandail 2 hours blood insulin and glucose[ （ 14.23 ± 2.35） mlU/L, （47.20 ± 10.26） mlU/L, （5.36 ± 0.91 ） mmol/L] than before weight - lost therapy[（32.54±7.13） mlU/L, （164. 53 ± 33. 60） mlU/L, （8. 75 ± 1. 09） mmol/L]（P〈0.01）.Conclusion The study indicated that weight- lost therapy is the is the best way to treat treat children with IGT,insulin resistance and prevent 2 -type diabetes.

关 键 词：肥胖症 糖耐量减低 胰岛素抵抗 

分 类 号：R723.14[医药卫生—儿科]