新生儿糖代谢紊乱的临床研究  

Clinical Study on Disturbance of Glycometabolism in Neonates

作　　者：刘艳[1] 常立文[1] 罗小平[1] 刘皖君[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院儿科,武汉430030

出　　处：《实用儿科临床杂志》2005年第6期536-537,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的分析新生儿糖代谢紊乱的相关因素,探讨其预防和治疗措施。方法住院新生儿1783例进行血糖监测。所有息儿监测至2次空腹血糖正常为止。计数资料采用X2检验。结果发生糖代谢紊乱295例,其中低血糖症176例,高血糖症52例,二者兼有67例。血糖异常与胎龄呈显著负相关(P=0.001);与出生体质量呈显著负相关(P<0.01);小于胎龄儿(SGA)易发生糖代谢紊乱;轻度窒息组血糖紊乱以低血糖症为主,重度窒息组血糖紊乱以高血糖症居多(P<0.01);血糖恢复时间与窒息程度呈显著正相关(P<0.01);血糖异常与感染程度星显著正相关(P=0.019);糖尿病母亲婴儿易患低血糖症。结论对高危儿应尽早进行血糖监测,对血糖异常者及时处理,以减少或避免后遗症发生。Objective To analyze the relative risk factors of disturbance of glucose metabolism in neonates. Methods From January 2000 to December 2002, blood glucose levels were systenmatically monitored in 1783 hospitalized infants. The blood sugar levels of all infants were monitored until the fasting values reached normal for at lea.st twice. Results Two hundred and ninety - five cases were found with disturbance of glycometabolism, 176 cases presented with hype, glycemia, 52 cases presented with hyperglycemia,and 67 cases presented with both hype, glycemia ,and hyperglycemia. The occurrence of abmormal glucose metabolism was negatively correla ted with the gestational age（ P= 0.01 ）. The occurrence of abnormal glyeonletabolism was negatively correlated with birth weight （ P 〈 0. 001 ）. The incidence of disturbance of glycometabolism in small gestational age （SGA） was significant higher than that in appropriate for ge.stational（AGA） （P = 0. 001 ）. The abnormality of glycometabolism in nfild or moderate asphyxiated infants was mainly hypoglycemia; while in infants with severe asphyxia were mainly hyperglycemia（ P〈 0.01 ）. The lasting time of abnormal blood glucose le vel was negatively correlated with the severity degree of asphyxia （ P 〈 0.01 ）. Incidence of abmormal blood sugar was positively related to the severity degree of infection （P 0. 019）. Hype, glycemia was very common in infants of diabetic mothers. Conclusions It is necessary to monitor the blood sugar level in early neonates, especially for those with high - risk factors. Early diagnosis and timely correction of abnormal blood sugar level are essential to reduce the possible adverse sequelae of glycometabolic disturbance.

关 键 词：婴儿 新生 糖代谢紊乱 低血糖 高血糖 

分 类 号：R722.1[医药卫生—儿科]