母血清IL-6和IL-10水平与早产绒毛膜羊膜炎关系的研究  

Relationship between Maternal Serum IL-6 and IL-10 Levelsand Preterm Labor with Chorioamnionitis

作　　者：刘玉梅[1] 曾蔚越[1] 

机构地区：[1]四川大学华西第二医院,四川成都610041

出　　处：《华西医学》2005年第1期45-46,共2页West China Medical Journal

摘　　要：目的 :研究白细胞介素 - 6 (IL - 6 )和白细胞介素 - 10 (IL - 10 )在早产合并绒毛膜羊膜炎孕妇血清中的变化情况 ,探讨IL - 6对早产绒毛膜羊膜炎的监测作用和IL - 10在母胎免疫耐受机制中的作用。方法 :采用酶联免疫吸附法对 2 9例早产孕妇和 15例正常足月孕妇血清中的IL - 6和IL - 10进行检测 ,分娩时取部分胎盘胎膜组织送病检。结果 :早产合并绒毛膜羊膜炎孕妇血清中IL - 6水平明显高于无绒毛膜羊膜炎孕妇及正常足月孕妇 ,差异有显著性 (P <0 0 5 ) ;早产无绒毛膜羊膜炎孕妇血清中IL - 10水平高于足月孕妇 ,差异有显著性 (P <0 0 5 )。结论 :母血IL - 6是预测早产宫内感染的一项有用的指标。IL - 10在维持正常妊娠中起重要作用。Objective： To investigate the change of maternal serum interleukin - 6 and interleukin - 10 levels in preterm labor with chorioamnionitis, and to study the effect of IL - 6 on monitoring preterm labor with chorioamnionitis and the function of IL - 10 in the mechanism of maternal - fetal immune tolerance. Methods： Serum levels of IL - 6 and IL - 10 in 29 eases of preterm la- bor and 15 eases of normal term labor were measured by enzyme - linked immunosorbent assay. The partial placenta were detected ＇after labor. Results： The level of serum IL- 6 in preterm labor with chorioanmionitis was significantly higher than that of without chorioamnionitis and term labor. （ P 〈 0.05）. The lefel of IL - 10 in preteml labor without chorioanmionitis was siglfificantly higher than that of term labor, （ P 〈 0.05） . Conclusion： Maternal serum IL- 6 is a useful marker for detection of preterm labor with intrauterine infection, and IL- 10 may plays an important role in remain normal pregnancy.

关 键 词：白细胞介素-6 白细胞介素-10 早产 绑毛膜羊膜炎 

分 类 号：R714.21[医药卫生—妇产科学]