支气管哮喘发作期一氧化氮及内皮素含量的研究  

Concentrations of Serum Nitric Oxide and Endothelin in Bronchial Asthmatic Attack

作　　者：王敏[1] 王捷[2] 王宝祥[3] 高墨生[1] 孙辉[1] 申志芬[1] 

机构地区：[1]解放军白求恩国际和平医院,石家庄050082 [2]解放军260医院,石家庄050041 [3]济南空军医院,济南250031

出　　处：《临床误诊误治》2005年第11期784-785,共2页Clinical Misdiagnosis & Mistherapy

摘　　要：目的:探讨一氧化氮(NO)及内皮素(ET)在支气管哮喘发病中的作用。方法:采用分光光度法和放射免疫分析法测定36例支气管哮喘发作患者和32例正常对照者血清NO及ET含量。结果:轻、中度支气管哮喘组血清NO及ET含量明显高于对照组(P<0.05),重度支气管哮喘组血清NO及ET含量亦明显高于对照组(P<0.01)。结论:支气管哮喘发作期血清NO及ET升高,说明二者参与了哮喘的病理生理过程,故血清NO及ET含量可作为判定支气管哮喘病情的重要指标。Objective ：To investigate the role of serum nitric oxide （NO） and endothelin （ET） in bronchial asthmatic attack. Methods ： Serum concentrations of NO and endothelin in 36 patients with bronchial asthmatic attack and 32 normal controls were measured with speetrophotometry and radioimmunoassay. Results：The serum concentrations of NO and ET in patients with mild and moderate bronchial asthmatic attack were significantly higher than those in normal controls （P 〈0. 05 ） ; they were also very significantly different in severe attack from those in normal controls （P 〈0. 01 ）. Conclusions：Serum NO and ET got increased in bronchial asthmatic attack,indicating that NO and ET were involved in the pathogenesis of bronchial asthmatic attack. Therefore,the serum concentrations of NO and ET might serve as an important index for judging the severity of bronchial asthma.

关 键 词：哮喘 一氧化氮 内皮素 

分 类 号：R562.25[医药卫生—呼吸系统]