大黄酚抗衰老作用的实验研究  

Experimental study on antisenility effect of Chrysophanol

作　　者：李淑娟[1] 张力[2] 张丹参[2] 沈丽霞[2] 董晓华[2] 武海霞[2] 李炜[2] 

机构地区：[1]天津医科大学 [2]河北北方学院,河北张家口075000

出　　处：《中国老年学杂志》2005年第11期1362-1364,共3页Chinese Journal of Gerontology

基　　金：河北省自然科学基金资助项目(2004000653)

摘　　要：目的探讨大黄酚对小鼠抗衰老的作用。方法采用避暗实验,观察大黄酚对学习记忆的影响;通过常压耐缺氧、断头耐缺氧、亚硝酸钠中毒造成的缺氧以及负重游泳实验,观察大黄酚对小鼠缺氧及耐力的影响;以A lC l3造成急性衰老小鼠模型,观察大黄酚对小鼠血中超氧化物歧化酶(SOD)活性的影响。结果大黄酚能明显改善记忆障碍、提高小鼠耐力、并且能明显提高急性衰老小鼠血中SOD活性。结论大黄酚具有一定的抗衰老作用。Objective To observe the effect of Chrysophanol on antisenility in mice. Methods The influence of Chrysophanol on mice＇s learning and memory was observed using the method of the one trial passive avoidance response-step-through test, the influence of Chrysophanol on mice＇s anoxia and tolerance was observed using the normal pressure hypoxia, beheaded hypoxia, histotoxic anoxia and weightcarried swimming training test,and the influence of Chrysophanol on the activities of superoxide dismutase （SOD）in plasma using AlCl3-induced acute senile mice model. Results Intracerebroventricular（icv） Chrysophanol could improve the impairments of memory acquisition, promote the tolerance and increase plasma SOD activities in the acute senile mice. Conclusions Chrysophanol has the action of antisenility.

关 键 词：大黄酚 抗衰老 学习记忆 耐力 超氧化物歧化酶 

分 类 号：R282.71[医药卫生—中药学]