阿柔比星A PELGE纳米粒的制备及质量评价  

Preparation of PELGE nanoparticles of aclarubicin A and their quality evaluation

作　　者：陈蜀[1] 张志荣[1] 段友容[1] 石海涛[1] 

机构地区：[1]四川大学药学院,成都610041

出　　处：《中国抗生素杂志》2005年第11期659-661,704,共4页Chinese Journal of Antibiotics

摘　　要：目的研究阿柔比星A PELGE纳米粒的制备及质量评价。方法通过共沉淀法制备阿柔比星A PELGE纳米粒;考察阿柔比星A PELGE纳米粒的形态、粒径、包封率、载药量、Zeta电位和体外释药。结果阿柔比星A PELGE纳米粒在透射电镜下均呈圆球形,分布均匀,平均粒径为105~137nm,平均包封率为76%~86%,平均载药量为7.6%~8.6%,平均Zeta电位为-25^-33mV。纳米粒的体外释药曲线可分为突释和缓释两部分,体外释药曲线以W e ibu ll方程拟合为好。PELGE共聚物中的PEG分子量和百分量改变对阿柔比星A PELGE纳米粒的粒径、包封率、载药量、Zeta电位和释药速率的影响不明显。结论PELGE纳米粒作为传输药物的载体是可行的,并为PELGE纳米粒的进一步研究提供了实验依据。Objective To study the preparation of aclarubicin A （ACRB-A） PELGE nanoparticles （ACRB-A-PELGE-NP） and their quality evaluation. Methods The ACRB-A-PELGE-NP were prepared by nanoprecipitation. The characteristics of the nanoparticles were presented in terms of morphology, size, encapsulation efficiency, drug loading, Zeta potential and the in vitro release. Results The ACRB-A-PELGE-NP in electron microscopy were spherical in shape, the average size ranged in 105～137nm; the average encapsula- tion efficiency ranged in 76%～86%; the average drug loading ranged in 7.6%～8.6%, the average Zeta potential ranged in -25 ～ 33mV, and the release of ACRB-A from the ACRB-A-PELGE-NP followed the Weiball equation. The PEG content and the PEG molecular weight in the PEI.GE copolymer had not obviously influenced by the size, encapsulation efficiency, drug loading, Zeta potential and the releasing rate of ACRB-A from the ACRB-A-PEI.GER-NP. Conclusion Results suggested that the PEI.GE nanoparticles used as the carrier for drug delivery system merit to be investigated further.

关 键 词：PELGE纳米粒 阿柔比星A 药物释放 

分 类 号：R944.9[医药卫生—药剂学]