中长期模拟失重大鼠骨骼肌线粒体钙含量和肌浆网Ca^（2＋）－ATP酶活性变化  

Changes of Ca 2+ in Mitochondria and Ca 2+ -ATPase Activity in Sarcoplasmic Reticulum (SR) in Rat after Simulated Weightlessness.

作　　者：孙亚志[1,2] 黄丽昀 张谦[1,2] 杨光华[1,2] 张敏[1,2] 

机构地区：[1]航天医学工程研究所 [2]北京医科大学病理生理教研室

出　　处：《航天医学与医学工程》1996年第3期195-197,共3页Space Medicine & Medical Engineering

摘　　要：为探讨失重对肌肉功能的影响，观察了中长期模拟失重时大鼠骨骼肌细胞内Ｃａ２＋转运功能变化，测定了比目鱼肌、腓肠肌线粒体钙含量和肌浆网（ＳＲ）Ｃａ２＋－ＡＴＰａｓｅ活性。结果是悬吊１５、３０ｄ大鼠比目鱼肌和腓肠肌线粒体Ｃａ＋２含量增加，肌浆网Ｃａ２＋－ＡＴＰ酶活性降低，说明中长期模拟失重肌细胞内Ｃａ２＋转运功能发生了改变，这可能是影响肌肉收缩特性的因素之一。In order to observe changes of Ca 2+ -transport in skeletal muscle during simulated weightlessness Ca 2+ content in mitochondria and (SR)Ca 2+ -ATPase activity in SR were determined before and after simulated weightlessness. The results showed that mitochondriaCa 2+ increased and (SR)Ca 2+ -ATPase activity decreased. This indicated that cellular calcuim transport function was changed. This change may be one of the important factors causing the decrease of muscular contractive function in simulated weightlessness.

关 键 词：模拟失重 肌收缩 线粒体 肌浆网 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]