两种巴布剂基质体外释放度研究  

Study on the Releasing Property of two Cataplasma Carriers

作　　者：刘淑芝[1] 彭丽华[1] 郭春燕[1] 李曼玲[1] 冯伟红[1] 康琛[1] 金日显[1] 

机构地区：[1]中国中医研究院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2005年第6期5-7,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：科技部"十五"重大科技专项(863计划);课题编号(2004AA223013)

摘　　要：目的:对两种不同骨架材料制成的巴布剂进行体外释放度的测定,比较其释放速率和释药规律。方法:仿照透皮吸收的扩散池法,采用改良的Franz扩散池装置,用高效液相色谱法测定,以吴茱萸中所含吴茱萸次碱为指标,研究体外释放度。结果:两种骨架材料制备的巴布剂,吴茱萸次碱释药速率略有差别,聚丙烯酸树脂与天然高分子物质组成的基质释药速率略高于聚丙烯酸树脂与半合成高分子物质组成的基质。体外释药随时间为一递增过程,释药模式符合骨架型结构的Higuchi方程。结论:两种骨架材料配方均具有较好的控释性能。Objectives： To compare the in vitro releasing rates of evodiamine and rutaecarpine in two kinds of cataplasma carriers. Methods： The in vitro reasing of evodiamine and rutaecarpine from the cataplasma carriers were measured, imitating the method of percutaneous absorption by using improved Franz＇ s diffusion cell and HPLC. Results ： The releasing rates of Evodiamine and rutaecarpine in the carrier made of acrylic resin copolymer and natural copolymers are higher than those in the carrier made of acrylic resin copolymer and compounded copolymers. And both their releasing processes fit to the Higtichi equation. Conclusion： The two kinds of Cataplasma carriers have good drug releasing properties.

关 键 词：巴布剂 释放度 吴茱萸次碱 高效液相色谱 

分 类 号：R283.6[医药卫生—中药学]