生脉注射液对肥厚心肌超微结构和钙泵功能的影响  

Effects of Shengmai Injection Solution on Myocardial Hypertrophy and Calcium Overload

作　　者：张亚臣[1] 陈捷[1] 吕宝经[1] 荣烨之[1] 

机构地区：[1]上海第二医科大学新华医院心血管内科,上海200092

出　　处：《上海第二医科大学学报》2005年第10期1022-1024,共3页Acta Universitatis Medicinalis Secondae Shanghai

基　　金：上海市教委青年基金(97QB36)资助项目

摘　　要：目的研究生脉注射液对慢性压力过负荷引起肌浆网钙泵功能紊乱的防治作用。方法建立腹主动脉狭窄大鼠模型。24只大鼠随机分为对照组(假手术组)、模型组和造模后生脉注射液治疗组。分别测定各组大鼠的心肌重量、钙含量和钙泵功能,观察超微结构。结果生脉注射液组与模型组比较,左心室重量与体重比明显下降,心肌组织总钙含量显著降低,肌浆网Ca2+-ATP酶对45Ca的摄取能力和水解活性均显著升高(P<0.05或P<0.01),心肌超微结构损伤程度明显减轻。结论生脉注射液不仅能防治心肌肥厚,而且能保护肌浆网钙泵功能,防止心肌钙超载损伤。Objective To study the effects of Shengmai injection solution on myocardial hypertrophy and calcium overload induced by hypertension in rats. Methods To establish the rat model with constriction of the abdominal aorta. Twenty-four rats were divided into control group, model group and Shengmei group. These three groups of rats were studied in blood pressure, heart weight, myocardial uhrastructure, myocardial calcium contents and the functions of sarcoplasmic reticular Ca^2＋ ATPase（SERCA）. Results Compared with the model group, the weight of left ventricle/ the weight of body in Shengmai group was decreased （ P 〈 0.05 ） , as well as the contents of myocardial calcium, while the myocardial uhrastructure and functions of SERCA were not damaged in rats. Conclusion Shengmai injection solution could not only prevent and treat myocardial hypertrophy, but also could maintain the functions of SERCA and prevent myocardial calcium overload.

关 键 词：生脉注射液 高血压 心肌肥厚 超微结构 钙超负荷 CA^2+-ATP酶 

分 类 号：R285.5[医药卫生—中药学]