动脉粥样硬化与骨质疏松的相关性研究  

Experimental Study on the Association of Atherosclerosis with Osteoporosis

作　　者：沈丽[1] 殷峻[1] 卢维晟[1] 杨旭峰[1] 姚俊宇[1] 王一尘[1] 

机构地区：[1]上海第二医科大学新华医院老年病科,上海200092

出　　处：《上海第二医科大学学报》2005年第10期1030-1033,共4页Acta Universitatis Medicinalis Secondae Shanghai

基　　金：上海市卫生局科研基金(004L13)资助项目

摘　　要：目的分析骨钙丢失与血管壁钙沉积之间的关系,并初步观察辛伐他汀对钙动态沉积的影响。方法28只清洁级雄性SD大鼠,分为正常对照组、V it D3组和辛伐他汀组。9周后处死大鼠,观察分析其动脉病理学改变和血管组织、骨组织钙含量的变化。结果与对照组大鼠比较,大剂量的V it D3在增加血管钙负荷的同时引发骨钙明显下降,统计学证实两者具有相关性(b=-0.015,P<0.01);辛伐他汀使大剂量V it D3所造成的骨钙丢失减少,血管钙沉积减轻(P<0.01)。结论V it D3造成的骨钙丢失并异常动员转移至血管可能是血管钙化与骨质疏松相关因素之一;辛伐他汀促骨形成,使骨钙在骨组织沉积增加的同时减轻血管钙化程度。Objective To study the association of atherosclerosis with osteoporosis. Methods Twenty-eight healthy male SD rats were divided into three groups： control, vitamin Da-treated and simvastatin-treated. Morphological changes in the aorta, calcium content in the aorta and bone were detected after 9 weeks intervention. Results The rats treated with toxic doses of vitamin D~ had significantly reduced bone calcium but elevated vascular calcium compared with the control. Furthermore, vascular calcium was negatively correlated with bone calcium（ b = -0. 015, P 〈0.01 ）. Simvastatin could alleviate calcium changes in the bone and aorta caused by vitamin Da （P 〈 0.01 ）. Conclusion Excessive calcium released from the bone by vitamin Da may be one of the common pathologic factors of atherosclerosis and osteoporosis. Simvastatin can promote bone formation and reduce vascular calcification.

关 键 词：动脉粥样硬化 骨质疏松 辛伐他汀 

分 类 号：R58[医药卫生—内分泌] R543.5[医药卫生—内科学]