罗格列酮对2型糖尿病大鼠胰岛β细胞的影响  

Effect of rosiglitazone on the function and morphology of pancreatic beta-cell in type 2 diabetic rats

作　　者：谷成英[1] 袁莉[1] 唐兆生[1] 刘赟[1] 祝炼[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院内分泌科

出　　处：《中华糖尿病杂志（1006-6187）》2005年第5期330-331,共2页

基　　金：教育部留学回国人员启动基金资助项目(2002);湖北省自然科学基金资助项目(2002AB136)

摘　　要：目的小剂量链脲佐菌素注射加高脂饮食诱导的2型糖尿病大鼠罗格列酮治疗8周,胰岛β细胞形态学及功能等明显改善,说明罗格列酮不仅改善胰岛素抵抗,也保护了胰岛β细胞功能。Type 2 diabetic rats induced by a little dose of STZ plus high fat diet were treated with rosiglitazone for 8 weeks. Islet ceil morphology and insulin release function were improved obviously after the treatment. This showed that rosiglitazone could protect beta cell function while relieving insulin resistance.

关 键 词：罗格列酮 2型糖尿病 胰腺Β细胞 功能 

分 类 号：R587.1[医药卫生—内分泌] R733.71[医药卫生—内科学]