早发2型糖尿病的临床特点分析  

Clinical characteristics in patients with early-onset type 2 diabetes

作　　者：朱志蔚[1] 许雯[1] 廖志红[1] 李延兵[1] 胡国亮[1] 翁建平[1] 

机构地区：[1]中山大学附属第一医院内分泌科,广州510080

出　　处：《中华糖尿病杂志（1006-6187）》2005年第5期351-352,356,共3页

基　　金：广东省科技厅重点资助项目(2KM050015)

摘　　要：目的比较早发和迟发2型糖尿病(T2DM)患者的临床特点。方法将304例诊断为T2DM的患者按诊断年龄不同分为早发组和迟发组,比较两组在体质指数(BMI)、血糖、血压、血脂、空腹C肽、家族史、微血管病变等方面的差异。结果与迟发组患者相比,早发组有高BMI、HbA1c、空腹C肽和甘油三酯,低高密度脂蛋白胆固醇,高视网膜病变和肾功能损害比例,更显著的家族聚集倾向。结论(1)早发T2DM患者有显著的家族聚集倾向和更严重的代谢紊乱。(2)早发T2DM患者患糖尿病肾病及视网膜病变的危险性较高。Objective To compare the clinical characteristics of early-and late-onset type 2 diabetes. Methods 304 patients with type 2 diabetes were recruited and divided into two groups： early-and late-onset groups which were defined as diagnosis at ≤40 and 〉40 years of age, respectively. Clinical characteristics, including BMI, blood pressure, blood glucose, HbA1c, lipids profiles, fasting C-peptide, family history, and microvascular complications, were compared between two groups. Results Early-onset patients had higher levels of BMI, HbA1c, TG and C-peptide, lower levels of HDL-C, and higher rates of nephropathy, retinopathy and familial history of diabetes while compared with late-onset group. Conclusion Early-onset patients present the clinical features of higher rates of family history and poorer metabolic profiles, which may contribute to the development of early-onset type 2 diabetes. The patients with early-onset type 2 diabetes were at high risk for accompanying nephropathy and retinopathy.

关 键 词：早发型 2型糖尿病 临床特点 

分 类 号：R587.1[医药卫生—内分泌]