158例乙肝患者重叠感染CMV的临床观察  

The clinical study on re-infected with CMV of 150 patients with hepatitis B

作　　者：王爱林[1] 袁宝山[1] 孙淑艳[1] 吴杨[2] 孟庆斌[3] 

机构地区：[1]吉林大学第一医院检验科,吉林长春130021 [2]吉林大学第一医院消化科 [3]吉林省人民医院

出　　处：《中国实验诊断学》2005年第5期786-787,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的了解乙肝病毒(HBV)感染者及健康人感染巨细胞病毒(CMV)状态及临床特征。方法采用酶联免疫吸附测定法(ELISA)对158例乙肝患者和160例健康体检者进行抗CMV-IgM和抗CMV-IgG检测。结果乙肝患者血清抗CMV-IgM阳性率为22.15%(35/158),抗CMV-IgG阳性率为78.48(124/158);而健康对照者血清抗CMV-IgM阳性率为2.5%(4/160),抗CMV-IgG阳性率为86.25%(138/160),两者抗CMV-IgG阳性率比较无显著性差异(P>0.05)而抗CMV-IgM阳性率比较有显著性差异(P<0.01)。结论抗CMV-IgM在乙肝患者的阳性率高于健康人,差异有非常显著性意义。可能因HBV感染诱导机体出现免疫应答低下或免疫调节功能紊乱,使机体对CMV易感或激活体内原已潜伏的CMV,从而使乙肝患者伴有活动性CMV感染,加重肝细胞活动性炎症反应和损伤程度。Objective To study the state and the clinical characteristic of health people and HBV carrier with CMV. Methods 158 patients with typeB bepatitis and 160 health people were detected for anti-CMV-IgM, IgG byELISA. Results In patients with FIB, the positive rate of both anti-CMV-IgM and IgG were 22.15% （35/158） and 78.48% （ 124/158）, respectively; In health people the positive rate were 2.5 % （4/160） and 86.3 %, respeetively. There was no remarkable difference in positive rate of anti-CMV IgG, but there was remarkable difference in positive rate of anti-CMV-IgM between two groups. Conclusion The high anti-CMV-IgM positive rate in patients with HB may be caused by low immune response when people were caught with HBV. Disorder in immune ruction made body be sensitive to CMV and activated the CMV hided in the body, and then hepatic cell was further injured.

关 键 词：CMV HBV 抗CMV-IgM 

分 类 号：R512.62[医药卫生—内科学]