临床常见革兰阳性球菌的耐药性分析  

Surveillance of bacterial resistance in Gram-positive cocci

作　　者：冯家范[1] 刘洋[2] 毕重秀[1] 王晶莹[3] 

机构地区：[1]吉林大学第二临床医院检验科,吉林长春130041 [2]吉林大学第二临床医院放射科 [3]吉林大学第三临床医院检验科

出　　处：《中国实验诊断学》2005年第5期794-796,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的了解我院临床分离的革兰阳性球菌对常用抗菌药物的敏感性.方法用K-B法检测2003年～2004年我院临床分离的革兰阳性球菌对常用抗菌药物的敏感性,按照美国国家临床实验室标准委员会(NCCLS)2004的标准进行.结果耐甲氧西林的金黄色葡萄球菌(MRSA)和耐甲氧西林的凝固酶阴性的葡萄球菌(MRCNS)的感染呈上升趋势,MRSA的检出率为63.2%,MRCNS的检出率79.8%,对于肠球菌,屎肠球菌的耐药率明显高于粪肠球菌,万古霉素对肠球菌有较高的抗菌活性.结论革兰阳性球菌的感染已经变得非常普遍,MRSA、MRCNS和肠球菌对于常用抗菌药物出现了较高的耐药率,因此,依据药敏实验的结果合理选用抗生素是非常必要的.Objective To investigate the susceptibility of clinical isolates of Gram-positive cocci in my hospital. Methods Bacterial susceptibility testing was carried out Gram-positive cocci of clinical isolates from 2003 - 2004, using Kirby-bauey methods. Results were interpreted according to NCCLS 2004. Results Methicillin-resistant Staphylococcus aureus（MRSA） and Methicillin-resistant coagulase-negative Staphylococcus （MRCNS） became important pathogens of nosocomial infections. MRSA accounted for 63.2% ,MRCNS accounted for 79.8%. To E. faecium and E. faecalis, swains of E. faecium were resistant than strains E. faecalis, Vancomycin were the most active agents against entcrococcal isolates. Conclusion Gram-positive cocci become more common and MRSA, MRCNS, enterococcal spp are highly resistant to commonly used antimicrobials, it is necessary to choose antibiotics based or results of susceptibility tests.

关 键 词：葡萄球菌 肠球菌 抗生素 耐药性 

分 类 号：R446.5[医药卫生—诊断学]