卡介菌多糖核酸对白癜风免疫调节作用及疗效的研究  

Study on Immunity Modulation and Clinical Efficacy of Polysaccharide Nucleic Acidfraction of Bacillus Calmette Guerin(BCG-PSN) for Treatment of Vitiligo

作　　者：佟春光[1] 张秀英[1] 何焱玲[1] 陈懿德[1] 

机构地区：[1]首都医科大学附属北京朝阳医院皮肤科,北京100020

出　　处：《中国皮肤性病学杂志》2005年第11期669-671,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨卡介菌多糖核酸(BCG-PSN)对白癜风的免疫调节作用及疗效。方法分别用流式细胞术和ELISA方法检测卡介菌多糖核酸治疗白癜风前后患者外周血T细胞亚群、IL-6和IFN-γ的水平。结果白癜风患者治疗前外周血CD4+百分比及CD4+/CD8+比值下降,CD8+百分比升高,IFN-γ水平降低。卡介菌多糖核酸治疗后,患者CD4+百分比及CD4+/CD8+比值较治疗前升高,CD 8+百分比降低,IFN-γ水平升高(P<0.05),IL-6水平无变化(P>0.05)。治疗组有效率为68.42%,对照组有效率31.58%,两组疗效差异有显著性(P<0.05)。结论卡介菌多糖核酸治疗白癜风可以显著改善患者的细胞免疫功能,提高其治疗有效率。Objective To evaluate the immunity modulation and clinical efficacy of polysaccharide nucleic acidfraction of bacillus calmette guerin （BCG-PSN） for treatment of vitiligo. Methods The level of T-lymphocyte sub-populations and IFN-γ,IL- 6 in the peripheral blood of all patients were measured by flow cytometry and ELISA methods before and after treatment with BCG- PSN. Results The study showed that the percentage of CD4 ^＋ cell and CD4^＋/CD8 ^＋ ratio were decreased, the percentage of CD^8＋ cell was higher ,the level of IFN-γ was lower before treatment in patient with vitiligo. After treating with BCG-PSN, the percentage of CD4 ^＋ ,CD4 ^＋/CD8^ ＋ ratio,the level of IFN-γ were significantly increased and the percentage of CD8^＋ was decreased than those before treatment（P 〈0.05）. After treating 3 months, the efficacy rate in the treatment group was 68.42% and the control group 31.58%. There was significant difference between both groups （P 〈 0.05 ）. Conclusion BCG-PSN can markedly improve cellular immunity function and clinical efficacy of patients with vitiligo.

关 键 词：白癜风 卡介菌多糖核酸 T细胞亚群 IFN-Γ IL-6 

分 类 号：R562.25[医药卫生—呼吸系统] R285.5[医药卫生—内科学]