破壁松花粉的毒理试验  

Toxic ologic al Research of Pollen Pini

作　　者：樊柏林[1] 田辉[1] 王护民[1] 宋毅[1] 付少华[1] 

机构地区：[1]湖北省疾病预防控制中心,湖北武汉430079

出　　处：《癌变．畸变．突变》2005年第6期380-382,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：背景与目的:检测破壁松花粉作为保健食品的安全性。材料与方法:按照常规方法进行小鼠经口急性毒性、小鼠骨髓微核试验、小鼠精子畸形试验以及大鼠30d喂养试验。结果:破壁松花粉对2种性别的SPF级昆明种小鼠在灌胃量达15g/kg下,2周内动物未见明显中毒症状。微核试验和精子畸形试验结果均为阴性。30d喂养试验结果表明:该受试物对Wistar大鼠的临床检查、血液学、生化学、脏器重量和系数以及病理组织学等指标无明显的毒性作用。结论:破壁松花粉可以通过急性毒性、微核试验、精子畸形试验和30d喂养试验的毒理学安全性评价。BACKGROUND ＆ AIM： To test the safety of pollen pini as a health food. MATERIAL AND METHODS： Acute toxicity test, bone marrow cell micronucleus test, mice sperm abnormality test and 30 d feeding study were performed to study the toxicity of pollen pini. RESULTS： In acute toxicity test, male and female KM mice were fed with 15 g/kg dose of pollen pini, no toxic symptoms were observed. The results of bone marrow cell micronucleus test and mice sperm abnormality test were negative. In the 30 d feeding test, no obvious toxic effects were detected in clinical examination, blood tests, biochemical tests, organ weights and pathological examination in treated Wistar rats. CONCLUSION： Pollen pini passed the toxicological tests and deemed safe as a kind of health food.

关 键 词：松花粉 急性毒性 微核 精子畸形 30 d喂养试验 

分 类 号：R994.4[医药卫生—毒理学]