肠露灌肠剂对乙酸诱发小鼠溃疡性结肠炎治疗的实验研究  

Experi mental Study ofChangluEnema in Treating Ulcerative Colitis Induced by Acetic Acid in Mice

作　　者：吴耀南[1] 肖玉琴[1] 陈一斌[1] 王文凡[1] 涂志红[1] 王瑞幸[2] 黄自强[2] 

机构地区：[1]厦门市中医院,福建厦门361001 [2]福建医科大学,福建福州350004

出　　处：《福建中医学院学报》2005年第4期30-32,共3页Journal of Fujian College of Traditional Chinese Medicine

基　　金：福建省卫生厅重点科研基金资助项目(Y09)

摘　　要：观察中药复方肠露灌肠剂对乙酸诱发小鼠溃疡性结肠炎(UC)模型的治疗作用。将实验小鼠随机分为正常组、模型组、肠露组、柳氮磺吡啶(SASP)组4组,给药治疗7d后,比较各组小鼠的疾病活动指数(DAI),结肠炎症反应及结肠组织病理学变化。结果:肠露对小鼠UC能明显减少疾病活动指数,与模型组比较有非常显著性差异(P<0.01);并能明显减轻结肠炎症反应,与模型组比较差异有显著性(P<0.05);病理检查示模型组小鼠结肠粘膜糜烂、溃疡形成、炎细胞浸润明显,肠壁增厚;肠露组小鼠结肠粘膜未见糜烂及溃疡形成,炎细胞浸润轻,粘膜轻度充血。结论:中药复方肠露灌肠剂对小鼠UC有明显的疗效。To observe the therapeutic effect of compounds（TCD） changlu enema（CLE） in treating ulcerative eolitis（UC） induced by acetic acid. The experimental mice were divided randomly into 4 groups, i.e. normal, model, CLE, and salieylazosulfapyridine（SASP）. To give them different therapy for 7 days and compare their DAI, inflammatory response and histopathologie changes of colons. Result： CLE group could obviously decrease DAI of UC and inflammatory response of colons, there were significant difference compared with the model group （p 〈 0.01, p 〈 0.05）. Pathologic exam showed that there were mueosa anabrosis, ulceration, inflammatory cell infiltration, and thicken intestinal walls in the colons of model group; but there were neither mucosa anabrosis nor ulceration, less inflammatory cell infiltration, and light mucosa congestion in CLE group. Conclusion： CLE has good therapeutic effect in treating ulcerative colitis in mice.

关 键 词：肠露 乙酸 溃疡性结肠炎 小鼠 实验研究 

分 类 号：R285.5[医药卫生—中药学]