柴胡滴丸的成型工艺与优化  

Encapsulation of Bupleurum dropping pill

作　　者：李亚琴[1] 

机构地区：[1]浙江工业大学药学院,浙江杭州310032

出　　处：《中成药》2005年第11期1254-1256,共3页Chinese Traditional Patent Medicine

摘　　要：目的:确立柴胡滴丸的最佳成型工艺。方法:以滴丸的平均丸重、变异系数和其圆整度等为评价指标,探讨了基质的选择,药物与基质的配比,滴制温度、滴速、滴距和冷凝液温度对滴丸成型性的影响。结果:柴胡滴丸最佳成型生产工艺是聚乙二醇4000∶聚乙二醇6000=3∶1。结论:。该工艺适用于滴丸实验室试验和工业化生产。AIM： To establish the optimum preparation process for Bupleurum dropping pill. METHODS： A series of signal tests have been studied for the choice of substrate, its proportion of substrate to drug, the dropping and cooling agent temperature and dropping speed to make average pill weight, weight variation and roundness up to grade. RESULTS- The best pills formatting process were a ratio of PEG4000 to PEG6000 （3：1 ）. CONCLUSION： This preparation method is suitable for both the laboratory test and the industrial production for Bupleurum dropping pill.

关 键 词：柴胡滴丸 成型 圆整度 重量差异 

分 类 号：R944[医药卫生—药剂学]