男性2型糖尿病患者睾酮及性激素结合球蛋白水平分析  

Testosterone and SHBG Levels in Men with Type 2 Diabetes Mellitus

作　　者：信中[1] 谢荣荣[1] 王召平[1] 张京秀[1] 袁申元[1] 

机构地区：[1]首都医科大学附属北京同仁医院内分泌科,邮政编码北京100730

出　　处：《微循环学杂志》2005年第4期33-34,37,共3页Chinese Journal of Microcirculation

摘　　要：目的探讨男性2型糖尿病患者睾酮及性激素结合球蛋白(SHBG)水平与非糖尿病人群的差异及意义。方法以化学发光法测定60名男性2型糖尿病患者及51名非糖尿病男性血清SHBG及总睾酮水平。结果男性2型糖尿病患者SHBG及总睾酮水平显著低于对照组(P<0.01);与对照组相比,糖尿病患者随年龄增加游离睾酮水平下降明显;多元逐步回归分析发现糖尿病患者游离睾酮水平与年龄、糖化血红蛋白呈负相关(r=-0.483、P<0.01,r=-0.257、P<0.05)。结论2型糖尿病患者SHBG及睾酮水平的降低是独立年龄、体重指数(BMI)因素之外的,游离睾酮水平同血糖控制有关,其原因尚待进一步探讨。Objective: To study the sex hormone binding goblin (SHBG) and testosterone levels in men with type 2 diabetes mellitus (T2DM).Method: The venous blood was drawn for the determination of SHBG and total testosterone(TT) levels of 60 men with T2DM and a control group consisted of 51 non-diabetic men.Results: The SHBG and TT values of diabetic men were significantly lower than those of the controls (P<0.01). There were significant negative correlations between free testosterone(FT)values with age in men with T2DM. This phenomenon also existed in non-diabetic men, but the degree was mild. In diabetic men, the FT values also negatively correlated to GHbA_ 1c besides age.Conclusion: Low levels of SHBG and testosterone generally exist in diabetic men and their FT values are negatively correlated to the chronic hyperglycemia. The cause-effect relationship between T2DM and sex hormones needs further research.

关 键 词：男性 2型糖尿病 睾酮 性激素结合球蛋白 糖皮质激素 雄性激素 

分 类 号：R587.1[医药卫生—内分泌]