血绒毛膜促性腺激素值对早期妊娠结局的诊断价值  

Diagnostic value of serumβ-Human Chorionic Gonadotropin on early pregnancy outcome

作　　者：金黎[1] 刘瑶[1] 林晓华[1] 黄桂花[1] 

机构地区：[1]深圳市宝安区人民医院妇产科,518101

出　　处：《中国妇幼保健》2005年第22期2925-2926,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨血β-绒毛膜促性腺激素(β-HCG)值对判断早期妊娠结局的临床意义.方法:对停经6～7周、尿HCG检查阳性、B超检查宫内未见妊娠囊的妊娠者60例(研究组),进行血β-HCG首次测定及72 h后再次测定,与同期正常妊娠者30例(对照组)进行对比.结果:研究组中,首次测定血β-HCG值＜1 000 mIU/ml 38例、＞1 000 mIU/ml 15例、＞4 000 mIU/ml 7例.对照组30例均大于4000mIU/ml.72 h后再次测定血β-HCG值呈倍数上升者,研究组14例,对照组30例.研究组不良妊娠结局为95%(57/60),其中流产发生率为65%(39/60),宫外孕发生率为30%(18/60),宫内早期妊娠为5%(3/60).对照组无不良妊娠结局.首次测定血β-HCG值的平均值在两组间有非常显著性差异(P＜0.001).再次测定血β-HCG的值,呈倍数上升者在两组间有非常显著性差异(P＜0.001).结论:β-HCG首次测定值及再次测定值的倍数上升关系,对B超检查宫内未见妊娠囊的早期妊娠者,具有判断异常或正常妊娠结局的临床价值.Objective： To explores the clinical diagnosis significance of β- Human Chorionic Gonadotropin （ β- HCG） on early pregnancy outcomes . Methods： Initial β- HCG test and retest 72 hours after the first ones were conducted on 60 pregnancy cases （ as the study group） 6 -7 weeks from menopause, with urine β- HCG positive and without signs of gestational sac when checked by Ultrasound B. Comparison with 30 normal pregnancies （ as the contrast group） was made to judge the pregnancy outcomes . Results： Among the 60 cases of the study group, the initial β-HCG test shown that 38 subjects＇β -HCG levels were below 1000mIU/ml, 15 higher than lO00mIU! ml and 7 higher than 4000mIU/ml. β- HCG levels of all the 30 subjects from the contrast group were higher than 4000mIU/ml. β- HCG levels of 14 subjects from the study group and 30 subjects from the contrast group had multiplied 72 hours later. The poor pregnancy rate was 95% （57/60）, the miscarriage incidence was over 65% （39/60）, and the ectopic pregnancy incidence 30% （18/60）, the early intrauterine pregnancy rate was 5% （3/60） in the study group. For the contrast group, no poor pregnancy outcomes had been detected. The difference of β-HCG average values between the two groups was remarkable as a result of the initial tests （P 〈0. 001 ）. Also, the retest results indicated that the multiple increases of β- HCG levels of the two groups were also different from each other （ P 〈 0. 001 ）. Conclusion： The multiple increases of β- HCG test provide clinical reference for judging normal or abnormal pregnancy outcomes especially for those early pregnancies showing no intrauterine gestation sacs under Ultrasound B detection .

关 键 词：Β-绒毛膜促性腺激素 早期妊娠 结局 

分 类 号：R714.15[医药卫生—妇产科学]