益气复智颗粒对多发梗死性痴呆模型大鼠的活血化瘀作用  

Effect of Yiqi Fuzhi Granule in Activating Blood Circulation and Removing Blood Stasis in Rat Models of Multiple Infarctional Dementia

作　　者：周建英[1] 严冬萍[2] 刘涛[3] 刘学凤[3] 

机构地区：[1]南京中医药大学科研处,南京210029 [2]南京中医药大学药学院,南京210029 [3]南京中医药大学基础医学院,南京210029

出　　处：《中药新药与临床药理》2005年第6期393-395,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：江苏省教育厅自然科学基金资助项目(编号99KJB360006)

摘　　要：目的观察益气复智颗粒对多发梗死性痴呆模型大鼠的活血化瘀作用。方法采用颈内动脉注射血栓的方法,复制多发梗死性痴呆大鼠模型,观察益气复智颗粒手术前、手术前后、手术后不同时间给药对模型动物血液流变学、血小板聚集、凝血活酶时间(TT)、凝血酶原时间(PT)、白陶土部分凝血活酶时间(KPTT)的影响。结果益气复智颗粒能明显改善多发梗死性痴呆模型大鼠血液流变性,降低血液黏度和血小板聚集率;其中以手术前及手术前后给药组作用更为明显。结论益气复智颗粒具有活血化瘀作用。Objective To observe the effect of Yiqi Fuzhi Granule on activating blood circulation and removing blood stasis in rat models of multiple infarctional dementia. Methods Internal carotid artery injection method was used to establish rat models of multiple infarctional dementia. The changes of blood theology, blood platelet aggregation, thromboplastin time, plasmozyme time and kaolin partial thromboplastin time before and after operation were observed. Results Yiqi Fuzhi Granule could markedly improve blood rheology in rat models of multiple infarctional dementia and reduce blood viscosity and blood platelet aggregation rate, the effect being obvious before operation. Conclusion Yiqi Fuzhi Granule has a good action of activating blood circulation and removing blood stasis.

关 键 词：益气复智颗粒 多发梗死性痴呆 大鼠 血液流变学 活血化瘀 

分 类 号：R285.5[医药卫生—中药学]