氧化锆基质HPLC柱填料研究进展  

Modification and Application of Zirconia-Based Packings in HPLC Separations

作　　者：敦惠娟[1] 赵惠敏[1] 陈立仁[2] 

机构地区：[1]河北师范大学化学学院,石家庄050016 [2]中国科学院兰州化学物理研究所,兰州730000

出　　处：《化学进展》2005年第6期1116-1122,共7页Progress in Chemistry

基　　金：国家自然科学基金(No.20375045);河北师范大学博士基金(No.L2004B09)资助

摘　　要：氧化锆具有很好的化学、机械和热稳定性,适合于碱性物质,特别是生物大分子的分离。氧化锆的色谱性能与硅胶形成很好的互补,具有广阔的应用前景。本文对氧化锆微球表面修饰方法及在色谱分析中的应用进行了综述分析。分析表明氧化锆是性能优异的色谱基质填料。Zirconia exhibits excellent chemical, thermal and mechanical stability. Recently, there has been an increasing importance in application of zireonia support for their good basic and bioanalytic suitability. Zirconia shows different selectivity from silica and it enriches the power of high performance liquid chromatography （HPLC）. In this review, the various modifications of zirconia packings, their application in HPLC separations are outlined. It has been found that zirconia is a promising HPLC packing support.

关 键 词：高效液相色谱(HPLC) 色谱填料 氧化锆 

分 类 号：O657.7[理学—分析化学]