多潜能性维持因子Nanog研究进展  

Progress on Novel Pluripotency-Maintaining Factor Nanog

作　　者：张运海[1] 方富贵[1] 利光辉[1] 章孝荣[1] 

机构地区：[1]安徽农业大学动物科技学院,安徽合肥230036

出　　处：《动物医学进展》2005年第11期18-21,共4页Progress In Veterinary Medicine

摘　　要：胚胎干细胞(ES)在可以无限增殖的同时具有分化为成体所有类型体细胞的潜能。上述特性直接决定了ES在医学、农业以及生物学基础研究方面具有巨大的潜在应用价值,尤其是在一些人类疾病的治疗上最为人们所看好。已知白血病抑制因子(leukemiainhibitory factor,LIF)是通过激活Stat3(Signal Transducers and Activators of Tran-scription 3,Stat3)来维持小鼠ES细胞自我更新的,然而LIF/Stat3并不是维持内细胞团(inner cell mass,ICM)以及人ES细胞处于多潜能状态的必需因素。这说明可能还存在其他调控机制来实现这一功能。Nanog则是近年来被发现的一个ES细胞自我更新维持因子,它可以独立地在LIF/Stat3因素撤去的情况下支持ES细胞的自我更新。文章重点介绍了Nanog因子的发现、编码基因的序列特征以及表达调控,期望为家畜ES细胞的研究提供有益的启示。Embryonic stem cells （ES） can undergo extended proliferation lifespan while keep the ability of multilineage differentiation. These characteristics enable ES cell to be of great potential applications in medicine, agriculture and basic research, especially in developing novel therapy for some human diseases. It is reported that leukemia inhibitory factor （LIF） can maintain the self-renewal ability of mouse ES cell through activating Stat3. However, interestingly, LIF/Stat3 is dispensable for maintenance of ICM and human ES cell, which suggest that there might exist another path. Recently a new pluripotency-maintaining factor called Nanog was found. Nanog alone can support the self-renewal of ES cell bypassing the LIF/Stat3 pathway. The present paper reviewed mainly the discovery of Nanog, its characteristic of genome sequence and expression of coding gene-Nanog.

关 键 词：NANOG 胚胎干细胞 白血病抑制因子 自我更新 多潜能性 

分 类 号：Q74[生物学—分子生物学]