降糖脂方对糖尿病伴高脂血症患者脂代谢及血液流变学的影响(英文)  

Influence of the prescription for lowering glucose and lipid on the lipid metabolism and hemorheology in diabetic patients with hyperlipidemia

作　　者：王琦[1] 王灿晖[2] 

机构地区：[1]南京医科大学第一附属医院中医科,江苏省南京市210029 [2]南京中医药大学温病教研室,江苏省南京市210029

出　　处：《中国临床康复》2005年第39期180-181,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:糖尿病患者常伴有脂代谢及血液流变学上的改变,这些改变是引起心脏病变的主要原素。目的:观察降糖脂方对糖尿病伴高脂血症患者脂代谢及血液流变学的影响。设计:随机对照观察。单位:南京医科大学第一附属医院中医科及南京中医药大学温病教研室。对象:选择1998-05/2000-06南京医科大学第一附属医院中医科和南京中医药大学国医堂103例糖尿病伴脂质代谢异常的患者,随机分为两组,降糖脂方治疗组(52例)和血脂康对照组(51例)。方法:治疗组服用降糖脂方,不使用其他降脂药。药用:山楂10g,红花10g,桃仁12g,丹皮10g,水蛭3g,丹参15g,西洋参2g,首乌15g,黄精12g,杞子12g,黄芪20g,日服1剂。对照组服用血脂康,2片/次(0.3g/片),3次/d,两组患者均于服药前及服药40d后抽血检查,分别测定血脂及血液流变学各项指标,并进行治疗前后对照比较。主要观察指标:降糖脂方对糖尿病患者胆固醇、三酰甘油、低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、血液流变学的影响。结果:共纳入103例患者,血脂分析全部完成数据采集,血液流变学完成75例数据采集,其余因费用等原因未做。①血脂各项指标比较:治疗组治疗后的三酰甘油、胆固醇、低密度脂蛋白-胆固醇、极低密度脂蛋白-胆固醇均比治疗前降低,高密度脂蛋白-胆固醇高于治疗前;对照组治疗后只有三酰甘油、胆固醇、低密度脂蛋白-胆固醇比治疗前降低。②血流变指标比较:治疗组治疗后的全血黏度·高切、全血黏度·中切、血黏度·低切、红细胞压积、血小板聚集率均比治疗前降低;而对照组只有血小板聚集率比治疗前降低。结论:降糖脂方可改善糖尿病性高血脂症患者的脂代谢及血液流变学指标。BACKGROUND： Diabetic patients are often accompanied with the changes in lipid metabolism and hemorheology, which are the main factors to cause cardiopathy.OBJECTIVE： To observe the influence of the prescription for lowering glucose and lipid on the lipid metabolism and hemorheology in diabetic patients with accompanied hyperlipidemia.DESIGN： A randomized control observation.SETTING： Department of Traditional Chinese Medicine, the First Affiliated Hospital of Nanjing Medical University; the Staff Room of Epidemic Febrile Disease, Nanjing Medical University.PARTICIPANTS： Totally 103 diabetic patients with abnormality of lipid metabolism, who were selected from the Department of Traditional Chinese Medicine, the First Affiliated Hospital of Nanjing Medical University and the Hall of Traditional Chinese Medicine of Nanjing Medical University between May 1998 and June 2000, were randomly divided into the group treated with the prescription for lowering glucose （n=52） and xuezhikang control group （n=51）.METHODS： In the treatment group, the patients were treated with the prescription for lowering glucose and lipid, which consisted of hawthorn fruit 10 g, safflower 10 g, peach seed 12 g, danpi 10 g, leech 3 g, danshen 15 g,American ginseng 2 g, fleece-flower root 15 g, king solomonseal rhizome 12 g, wolfberry fruit 12 g, astragalus root 20 g, one dose every day, and no other drugs for lowering lipids were used. In the control group, the patients were treated with xuezhikang,, 2 tablets for each time （03 g per tablet）, 3 times a day. The blood samples of all the patients in both groups were drawn and examined before medication and 40 days after medication, the indexes of blood lipids and hemorheology were detected respectively, and the results before and after treatment were compared.MAIN OUTCOME MEASURES： The influence of the prescription for lowering glucose and lipid on the cholesterol, triglyceride, low density lipoprotein cholesterol （LDL-C）, very low density lipoprotein cholesterol （V

关 键 词：糖尿病 高血脂症 降血脂药 载脂蛋白类 血液流变学 

分 类 号：R587.1[医药卫生—内分泌]