前列腺栓的急性毒性实验研究  

The Investment of acute toxicity prostate suppository

作　　者：袁天祥[1] 陈荣[1] 王喜蜂[1] 王效珍[1] 金关键[1] 

机构地区：[1]武警河南总队医院药剂科,河南郑州450052

出　　处：《武警医学院学报》2005年第6期509-510,共2页Acta Academiae Medicinae CPAPF

摘　　要：[目的]观察前列腺栓的急性毒性.[方法]用简化机率法,计算小鼠给药的半数致死量(LD5o).[结果]前列腺栓原料粉灌胃给药的半数致死量(LD50)为992.43 mg/kg.95%可信限为796.16～1 238.80 mg/kg.[结论]前列腺栓的半数致死量为有效剂量的8.8倍,因而其用药安全性是可靠的.[Objective] To investigate the acute toxicity of prostate suppository. [Methods] Count the value of the LD50 of prostate suppository offering to mouse by the way of simplified rate. [ Results] The LD50 of prostate suppository is 992.43 mg/kg （offering to mouses by medical powder）. The confidence limit of 95% is 796.16 - 1 238.80 mg/kg. [Conclusion] The safty of prostate suppository in clinical therapy is dependable because of the LD50 of which is 8.8 times of the normal dosage.

关 键 词：前列腺栓 急性毒性 LD50 

分 类 号：R983[医药卫生—药品]