甲硝唑治疗实验性肺螨病的疗效观察  

Observation on the curative effect of metronidazole for the treatment of experimental pulmonary acariasis

作　　者：戴忠辉[1] 陈兴保[1] 胡守锋[1] 

机构地区：[1]蚌埠医学院形态学实验室,蚌埠233003

出　　处：《中国人兽共患病杂志》2005年第11期1025-1027,共3页Chinese Journal of Zoonoses

摘　　要：目的观察甲硝唑治疗实验性肺螨病的治疗效果。方法把纯净的活螨注入家兔气管形成肺螨病的动物模型。40d后用甲硝唑(药物浓度为50mg/ml)鼻饲家兔,35mg/kg/d,每天2次,每疗程7d,共二个疗程,间隔7d。并比较螨接种前后,治疗前后兔体内的嗜酸性粒细胞、螨抗体、X胸片及肺部病变的变化。结果螨接种后兔体内的嗜酸性粒细胞(2.948×109/L)明显高于螨接种前嗜酸性粒细胞的计数(0.8387×109/L)(t=7.28,P<0.01)。治疗后,兔体内的嗜酸性粒细胞明显下降,从3.192×109/L下降到1.617×109/L(t=3.15,P>0.01)。抗体水平也明显下降,为未治疗组抗体水平的23.63%(t=4.59,P<0.01)。X胸片及肺部病变有明显的改善。结论甲硝唑在治疗实验性肺螨病中有很好的疗效。To observe the curative effect of metronidazole for the treatment of experimental pulmonary acariasis, dean living mites were injected to the trachea of rabbits to form the animal model of pulmonary acariasis, 40 days later they were treated by nose raise with metronidazole （the drug concentration was 50mg/ml） for 14 days, 35mg/kg/d, twice a day, 7 days as a period of treatment, two periods with an interval of 7 days. Moreover, eosinophils and level of mite antibodies, X-rag chest film of rabbits and pulmonary pathological changes before and after mites inoculation, before and after treatment were determined. It was found that the number of eoxinophils in the body of rabbits after mites inoculation （2.948 ×10^9/L） were evidently higher than that before mites inoculation （t = 7.28, P 〈 0.01）. After treatment with metronidazole, eosinophils declined from 3.192 ×10^9/L to 1. 617 ×10^9/L （t =3.15, P〈0.01）. The level of mite antibodies of treated group was 23.63% of untreated group at same times（t =4.59, P〈0. 01）. X-ray chest film and pulmonary pathological changes had evidently improved. It concludes that Metronidazole is very effident for the treatment of the experimental pulmonary acariasis.

关 键 词：甲哨唑 实验性肺螨病 治疗效果 

分 类 号：R384.8[医药卫生—医学寄生虫学]