微波辐射下一步合成4-芳基-3-甲基-6-氧代-1-苯基-4,5,6,7-四氢吡啶并[2,3-c]吡唑  

One-step Synthesis of 4-Aryl-3-methyl-6-oxo-1-phenyl-4,5,6,7-tetrahydropyrido[2,3-c]pyrazole under Microwave Irradiation

作　　者：屠树江[1,2] 朱松磊[3] 邵政[3] 邹翔[3] 纪顺俊[1] 张勇[1] 

机构地区：[1]苏州大学化学化工学院 [2]徐州师范大学化学系徐州221116 [3]徐州师范大学化学系

出　　处：《有机化学》2005年第12期1552-1555,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20372057);江苏省自然科学基金(No.BK2001142);江苏省苏州大学化学及化学工程有机合成重点实验室开放基金(No.S8109111);江苏省药用植物生物技术重点实验室基金(No.01AXL14)资助项目

摘　　要：以芳醛、麦氏酸和3-甲基-1-苯基-5-氨基吡唑为原料,经微波辐射一步得到4-芳基-3-甲基-6-氧代-1-苯基-4,5,6,7-四氢吡啶并[2,3-c]吡唑衍生物,反应2～6min完成,产率高.产物结构通过红外、核磁共振、元素分析及单晶X射线分析确证.A series of 4-aryl-3-methyl-6-oxo-l-phenyl-4,5,6,7-tetrahydropyrido[2,3-c]pyrazoles were synthesized by one-step condensation of arylaldehydes with meldrum acid and 5-amino-3-methyl-l-phenyl- pyrazole under microwave irradiation. The reaction was completed in 2～6 rain with good yields. All the products were characterized by IR, 1H NMR spectra and elemental analysis, and 4 c was determined by the X-ray diffraction analysis.

关 键 词：吡啶并[2 3-c]吡唑 微波辐射 一步合成 

分 类 号：O626.32[理学—有机化学]