微波辐射下三组分“一锅法”合成5-芳基-1,5,6,7,8,9-六氢化-2H-吡唑[5,4-b]并喹啉-6-酮  

Facile Three Component One-pot Synthesis of 5-Aryl-1,5,6,7,8,9-hexahydro-2H-pyrazolo[5,4-b]quinolin-6-one Derivatives under Microwave Irradiation

作　　者：华国平[1] 徐佳宁[2] 屠树江[2] 王倩[2] 张金鹏[2] 朱晓彤[2] 李团结[2] 朱松磊[2] 章晓镜[2] 

机构地区：[1]徐州建筑职业技术学院,徐州221008 [2]徐州师范大学化学系江苏省药用植物生物技术重点实验室,徐州221116

出　　处：《有机化学》2005年第12期1610-1614,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20372057);江苏省苏州大学化学及化学工程有机合成重点实验室开放基金(No.S81009111);江苏省药用植物生物技术重点实验室基金(No.01AXL14)资助项目

摘　　要：在微波辐射下以芳醛、1,3-环己二酮或达米酮和氨基吡唑为原料,用乙二醇作能量转移剂,三组分“一锅法”快速合成了一系列吡唑[5,4-b]并喹啉类化合物.该方法速度快(30～90s),产率高(88%～98%),环境友好.产物结构通过红外光谱、核磁共振谱和元素分析证实,化合物4e的单晶经X射线衍射分析,进一步确证了产物结构.A series of 5-aryl-1,5,6,7,8,9-hexahydro-2H-pyrazolo[5,4-b]quinolin-6-one dervatives were synthesized by the three component one-pot reaction of 5-amino-3-methyl-l-phenypyrazole with aromatic aldehydes and dimedone or 1,3-cyclohexanedione under microwave irradiation using glycol as energy trans- fer agent. This method has the advantage of excellent yields （88%～98%）, short reaction time （30～90 s） and being environmental friendliness. The structures of the products were identified by IR, NMR spectra, elemental analysis and X-ray crystallograghic of 4e.

关 键 词：吡唑并喹啉 氨基吡唑 微波辐射 

分 类 号：O626.2[理学—有机化学]