良性前列腺增生组织中转化生长因子受体与成纤维生长因子受体表达的相关性研究  

Correlation study on the expression of transforming growth factor-β type I receptor and fibrohlast growth factor type I receptor in BPH

作　　者：吴刚[1] 那彦群[2] 夏同礼[2] 薛兆英[2] 郭应禄[2] 

机构地区：[1]江苏省徐州市第三人民医院泌尿外科,221005 [2]北京大学泌尿外科研究所,100034

出　　处：《河北医药》2005年第11期805-806,共2页Hebei Medical Journal

摘　　要：目的探讨转化生长因子βI型受体(TGFβRI)与成纤维生长因子受体(FGFR)在良性前列腺增生(BPH)组织中表达的意义及其相关性。方法采用免疫组化法研究两种受体在31例BPH标本中表达的意义,并与正常前列腺组织22例作对照研究。结果TGFβRI在BPH上皮、间质组织中的表达显著高于正常前列腺组织(P<0．05);FGRβRI在BPH上皮组织中的表达显著高于正常前列腺组织(P<0．05),而在BPH间质组织中的表达差异无显著性。在BPH间质组织TGFβRI与FGFRI的表达呈正相关(相关系数r值为0．358,P<0．05)差异具有统计学意义。结论TGFβRI与FGFRI在BPH上皮中表达增高以及在间质中的表达呈正相关,说明两者之间具有协同作用,提示两者可能参与了BPH的发生和病理过程。Objective To investigate the expressions of transforming growth factor-β type Ⅰ receptor （TGF- BR Ⅰ ） and fibroblast growth factor type Ⅰ receptor （FGFR Ⅰ ） in human prostatic tissue and benign prostatic hyperplasia （BPH）. Methods The expressions of TFGBR Ⅰ and FGFR Ⅰ were detected by immunohistochemistry in human prostatic tissue of 31 patients with BPH and 22 normal subjects for studying the relativity between them.Results The positive expressions of TGFBR Ⅰ in epithelial and interstitial tissue in BPH were significantly higher than those in normal prostatic tissue （ P 〈 0.05）. The positive expression of FGFR Ⅰ in epithelial tissue in BPH was much higher than that in normal prostatic tissue （ P 〈 0.05）, however, which was not in interstitial tissue. The expression of TGF- BRI was closely related with that of FGFRI in interstitial tissue in BPH （ r =0.398, P 〈0.05）.Conclusion The aberrant expression of TGFBR Ⅰ and FGFR Ⅰ might contribute to the pathogenesis and pathological progress of BPH.

关 键 词：前列腺增生 生长因子 受体 

分 类 号：R697.3[医药卫生—泌尿科学] R735.2[医药卫生—外科学]