注射用苦碟子(KDZ)对脑缺血的保护作用  

Protective effect of KDZ injection on cerebral ischemia

作　　者：王彩霞[1] 刘玉兰[2] 赵强[3] 

机构地区：[1]石家庄制药集团中奇公司,050051 [2]沈阳药科大学药学院,辽宁市110016 [3]河北华荣制药有限公司,050051

出　　处：《河北医药》2005年第11期860-861,共2页Hebei Medical Journal

摘　　要：目的观察注射用苦碟子(KDZ)对脑缺血的保护作用。方法采用断头法和常压耐缺氧法,观察注射用KDZ对小鼠耐缺氧能力的影响;采用跳台法,观察注射用KDZ对缺血再灌注小鼠学习记忆功能障碍的作用;采用化学法,观察注射用KDZ对缺血再灌注小鼠脑组织中超氧化物歧化酶(SOD)、丙二醛(MDA)的影响。结果注射用KDZ可显著延长小鼠断头喘气时间及常压耐缺氧存活时间;可改善缺血再灌注引起的学习记忆障碍,延长潜伏期,减少错误次数;增强缺血再灌注小鼠脑组织SOD活力,降低MDA含量。结论注射用KDZ对脑缺血具有保护作用。Objective To observe the protective effect of KDZ injection on cerebral ischemia. Methods The effect of KDZ on normobaric hypoxia tolerant ability in mice was observed by decapiation and normobaric hypoxia tolerant method;the effect of KDZ on the disturbance of learning and memory ability in mice of ischemia-reperfusion was observed by step down test;the effect of KDZ on the activities of SOD and MDA in cerebral tissue of ischemia-reperfusion mice was observed by spectrophotometric assay. Results KDZ injection could obviously prolong the gasping time after cutting head in mice and the survival time of normobaric hypoxia tolerant in mice. KDZ injection could markedly improve the disturbance of learning and memory caused by ischemia-reperfusion, prolong the latency, reduce the error number and obviously increase the activities of SOD and MDA in cerebral tissue of ischemia-reperfusion mice. Conclusion KDZ injection has protective effects on cerebral ischemia injury.

关 键 词：注射用KDZ 脑缺血 缺血再灌注 

分 类 号：R978.11[医药卫生—药品] R743.31[医药卫生—药学]