局麻止痛膜的制备及质量控制  

Preparation and Quality Control of Jumazhitong Film

作　　者：杨宝峰[1] 韩永龙[1] 宫学惠[1] 董慧萍[1] 李丽辉[1] 

机构地区：[1]黑龙江大庆油田总医院,大庆市163001

出　　处：《中国药房》2005年第22期1712-1713,共2页China Pharmacy

摘　　要：目的:制备局麻止痛膜并建立其质量控制方法.方法:以聚乙烯醇-124为基质制备局麻止痛膜,并采用高效液相色谱法测定其中主药盐酸达克罗宁的含量.结果:盐酸达克罗宁检测浓度在40.8～408μg/ml范围内与峰面积线性关系良好(r=0.9 998),平均回收率为101.3%(RSD=1.3%,n=6).结论:局麻止痛膜的制备工艺简单,质量稳定,控制方法可行.OBJECTIVE： To prepare jumazhitong film and establish its quality control method. METHODS： The jumazhitong film former was made with PVOH- 124 as the base,the content of the principal agent -dyclonine hydrochloride was determined by HPLC. RESULTS： Good linear relation was achieved when the detection concentration range of dyclonine hydrochloride was 40.8- 408μg/ml（ r = 0.9 998）, the average recovery was 101.3 % （RSD=1.3%, n = 6）. CONCLUSION ： The preparing technique of jumazhitong film former is simple, its quality is stable and the control method is feasible.

关 键 词：局麻止痛膜 盐酸达克罗宁 制备 质量控制 

分 类 号：R986[医药卫生—药品] R927.2[医药卫生—药学]