复方甘草酸苷治疗活动性肝炎肝硬化的疗效观察  

Observation on Efficacy of Compound Glycyrrhizin in Treating Chronic Hepatitis B Complicated with Active Cirrhosis

作　　者：宋建华[1] 王连香[1] 王支福[1] 

机构地区：[1]解放军第88医院,泰安市271000

出　　处：《中国药房》2005年第22期1729-1730,共2页China Pharmacy

摘　　要：目的:观察复方甘草酸苷长程治疗活动性肝炎肝硬化的疗效。方法:58例活动性肝炎肝硬化患者静脉注射复方甘草酸苷60ml,1次/d,连用18mo。观察治疗前、后的临床症状、体征、生化指标、病毒学指标的变化。结果:治疗后有35例患者活动性肝硬化得到控制,5例患者腹水消失,17例患者恢复工作;HBV-DNA定量下降>103拷贝/ml,HBeAg转阴率达33.3%。结论:复方甘草酸苷长程治疗活动性肝炎肝硬化,可改善患者肝功能,阻止病情进展,提高其生活质量。OBJECTIVE： To observe the long term therapeutic effect of compound glycyrrhizin in treating active cirrhosis following chronic hepatitis B. METHODS： 58 patients with active cirrhosis received compound glycyrrhizin 60ml intravenously once a day for 18 consecutive months. The changes in clinical symptoms, signs, biochemical indicators, virology indices after treatment were observed. RESULTS： 35 cases of active cirrhosis remained stable after treatment, ascites disappeared in 5 cases, and 17 patients returned to work. The quantitated decrease in HBV - DNA was greater than 10^3 copies/ml, HBeAg negative rates reached 33.3%. CONCLUSION： Longterm treatment with compound glycyrrhizin for active cirrhosis following hepatitis B can improve liver function, prevent the worsening of patients＇ condition, and improve life quality.

关 键 词：慢性乙型肝炎 肝硬化 复方甘草酸苷 疗效 

分 类 号：R975.5[医药卫生—药品]