心房可兴奋间期对山羊心房颤动稳定性的影响  

Effects of atrial excitable period on the stability of atrial fibrillation in goats

作　　者：单兆亮[1] 王玉堂[1] 时向民[1] 闫俊瑾[1] 周俊彦[1] 国建萍[1] 王卫华[1] 李天德[1] 

机构地区：[1]解放军总医院心内科,北京100853

出　　处：《中华心血管病杂志》2005年第11期992-994,共3页Chinese Journal of Cardiology

基　　金：全军医药卫生"十五"计划科研基金课题(01MB074)

摘　　要：目的研究山羊心房可兴奋间期(EP)在心房颤动(房颤)稳定过程中的作用.方法在10只山羊的左心房游离壁外膜缝合电极片,利用自制的房颤刺激器于体外发放50 Hz的刺激1 s,每次间隔2 s,诱发维持时间超过24 h的持续性房颤.定期终止刺激,记录房颤自发持续时间,计算平均房颤波周长(AFCL),并在房颤持续过程中利用感知房颤波发放刺激夺获心房的方法测量房颤时心房有效不应期(ERPAF),计算EP(EP= AFCL-ERPAF).结果 8只山羊完成实验,均在6～16(9.3±4.6)d内诱发出持续超过24 h的持续性房颤.在房颤自发维持达3～10 min和24 h时的AFCL分别为98.3 ms ±11.0 ms与84.9 ms ± 5.2 ms ,P<0.05;ERPAF分别为90.5 ms ±13.2 ms与63.0 ms ± 4.8 ms,P<0.05;EP分别为7.8 ms ± 2.4 ms与21.9 ms ± 3.5 ms,P<0.05.结论心房ERPAF的缩短大于AFCL的缩短,使得EP持续性增宽,可能在房颤的稳定过程中起重要作用.Objective To investigate the effects of atrial excitable period （EP） on the stability of atrial fibrillation （AF） in goats. Methods Ten female goats were instrumented with epicardial electrodes patches on the left atrium （LA） free wall AF was induced and maintained by a home-made stimulator with frequency of 50 Hz at a 1-second duration and a 2-seconds interval. The stimulator was disconnected regnlarly. AF-induced duration, average AF cycle length （ AFCL）, and atrial effective refractory period during AF （ ERPAF ） were measured; EP was calculated by AFCL - ERPAF. Results Eight goats were studied. Persistent AF （ 〉24 h） could be induced in all the 8 goats within 6 - 16 days. When the induced AF lasted for 3 - 10 rain or 24 h, the AFCL was 98.3 ms ± 11.0 ms and 84. 9 ms ± 5.2 ms （P 〈 0. 05 ）, respectively. ERPAF was 90. 5 ms ± 13.2 ms and 63.0 ms ± 4. 8 ms （P 〈0. 05）, respectively,and EP was 7.8 ms ± 2. 4 ms and 21.9 ms ± 3.5 ms （P 〈 0. 05 ）, respectively. Conclusion The decrease in ERPAF is more significant than the shortening in AFCL, resulting in the gradually widening of EP which may contribute to the perpetuation of AF.

关 键 词：心房颤动 电生理学 山羊 

分 类 号：R541.75[医药卫生—心血管疾病] R541.7[医药卫生—内科学]