新疆地区获得性免疫缺陷综合征的流行特征和趋势  

The epidemic characters and tendency of HIV/AIDS of Sinkiang

作　　者：彭红[1] 夏志刚[1] 范淑英[1] 赵素元[1] 

机构地区：[1]新疆维吾尔自治区人民医院检验科,830001

出　　处：《中华检验医学杂志》2005年第11期1151-1153,共3页Chinese Journal of Laboratory Medicine

摘　　要：目的从血清学的检测结果探讨新疆地区获得性免疫缺陷综合征的流行特征和趋势。方法2001至2004年本院对外科手术之前常规检测和临床各科疑诊送检血清36021份,应用ELISA和金标法筛检后送区疾控中心艾滋病监测中心WB法确认,RTPCR方法测HIVRNA的载量,流式细胞仪检测CD细胞。结果抗HIV阳性259例,占0.714%。女性占38%(97/259)有增高倾向并出现宫内感染3例。16～35岁占80%,维族占85.6%,静脉吸毒和无业人群各占94%和67.7%。北疆占83.3%,南疆占8.69%。病毒核酸检出率达50%,其中104～105cop/ml占76%(19/25),CD4、CD8CD4/CD8均有异常,其中CD4/CD8比值降低达96%,CD4降低56%,CD8升高60%,住院病人逐渐增多。因此感染死亡者占80%,自发骨折占外科16.7%。结论血清学抗HIV、HIVRNA,CD细胞检测证实新疆发病晚,进展快,女性感染率上升存在宫内感染,已进入发病和死亡的增长期,抗病毒治疗势在必行。Objective To study the epidemic characters and tendency of HIV/AIDS （Human immunodeficiency virus/Acquired immunodeficiency syndrome） from serologic check results. Methods 36 021 specimens of suspected clinical cases and routine cases before surgery in Xinjiang Urumqi Uiger Municipal People＇s Hospital were detected from 2001-2004. At first, these cases weresereened by ELISA （Enzyme-linked immunoadsordent assay） , then ascertained by desease-control center and AIDS surveillance systems through WB , HIV RNA were estimated by the application of RT-PCR , CD cell were counted with flow cytometry. Result Prevalence figures have risen sharply from 1999-2001 and increased steadily since 2002 , the positive rates of anti-HIV were 0. 714% （259 cases） . 38 percents cases were female （97/259）, female ratio had the increasing trend and 3 cases were found as intrauterine infection . 80% cases were adolescent（16 year old to 35 year old） , 85.6% cases were Uiger minority , 94% and 67. 7% cases were drug abuse through vein and non-occupation respectively. 83.3% and 8. 69% cases were found in north and south of Xinjiang respectively. The positive rates of virus nucleic acid were 50% , in which 76% （ 19/25 ） were 104- 105 cop/ml. CD4,CD8, CD4/CD8 were all abnormal, CD4/CD8 ratio decreased to 96% ,The number of CIM cells was remarkably reduced 56% ; while CD8 cells was significantly rised 60% ;Inpatients increased gradually. Among them , 80% cases were dead due to infection , 16. 7% surgical cases were fracture spontaneously. Conclusion The serologic detection of anti- HIV , HIV RNA , CD cell counts had confirmed AIDS episode later ; The progress was more rapidly; infectious rate of female was increased and followed intrauterine infection in Xinjiang. The numbers of episode and death were in growth stage , antivirus therapy were imperative.

关 键 词：HIV 淋巴细胞计数 

分 类 号：R512.91[医药卫生—内科学] R511.1[医药卫生—临床医学]