甲氧西林耐药金葡菌所致实验性心内膜炎的研究  

EXPERIMENTAL ENDOCARDITIS CAUSED BY MRSA IN RABBITS

作　　者：魏瑾[1] 李家泰[1] 

机构地区：[1]北京医科大学临床药理研究所

出　　处：《中国临床药理学杂志》1996年第1期46-50,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金

摘　　要：本研究采用ｍｅｃＡ基因阳性的ＭＲＳＡ菌株建立了兔实验性心内膜炎模型。包括：动脉插管术、静脉感染ＭＲＳＡ、分组进行药物治疗、取血、赘生物及脾、肾组织培养及细菌计数。经国产抗ＭＲＳＡ有效药物去甲万古霉素治疗：静脉注射２０ｍｇ／ｋｇ，一天３次，连续给药４ｄ。结果对照组即未给药治疗组培养结果，菌量一般达到１０４ＣＦＵ／ｇ以上，而治疗组在给药后各项指标均为阴性。证明此模型可用于抗ＭＲＳＡ新药体内抗菌作用的评价。The experimental aortic valve endocarditis caused by MRSA with mecA gene positive was established in rabbits.The main procedures were as follow:1.arteral cannulation;2. intravenously infected with MRSA;3.randomly divided into two groups:one group received medical treatment.the other didn't;4.counted number of organisms in blood.vegetation.spleen and kidney.Animals received treatment by given norvancomycin: i.v.,20mg/kg every 8 hours,for 4 days. Results showed that the number of organisms were 104 CFU/g in non treatment group but no bacterial counts in blood.vegetation. spleen and kidney after treatment.So the model be used for evaluation in vivo activity of new antimicrobial agents against MRSA.

关 键 词：金黄色葡萄球菌 MECA基因 心内膜炎 

分 类 号：R542.41[医药卫生—心血管疾病]