绞股蓝总皂甙对正常人及麻醉犬缺氧性肺血管收缩反应的影响  

Effects of gypenosides on hypoxic pulmonary vasoconstrictionin healthy men and anesthetised dogs

作　　者：陈刚[1] 汪雄[1] 余涓[1] 李莉[1] 

机构地区：[1]同济医科大学郧阳医学院病理生理教研室,福建医学院病生教研室

出　　处：《中国病理生理杂志》1996年第1期86-89,共4页Chinese Journal of Pathophysiology

摘　　要：本文研究绞股蓝总皂甙（ｇｙｐｏｎｏｓｉｄｅｓ，ＧＰｓ）对血流动力学及缺氧性肺血管收缩反应（ＨＰＶ）的影响。１４名男性志愿者口服ＧＰｓ（１８０ｍｇ／ｄ）２０日后，基础血流动力学指标无显著变化，但ＨＰＶ显著降低（ΔＰＶＲ％从５３．１％降至１４．１％，ΔＰｐａ％从４３９％降至１８．７％，Ｐ＜０．０５）。服药后血小板活化程度、血浆血管紧张素Ⅰ、Ⅱ含量都明显降低（Ｐ＜０．０５）。１４只麻醉犬静脉注射ＧＲｓ后，体、肺动脉压急剧下降，注药后３０．４５～６０ｍｉｎ缺氧时，ＨＰＶ显著减弱，ΔＰＶＲ由给药前的４０．４％分别降至０．６％、１０．８％（Ｐ＜０．０５）。给药后血浆丙二醛含量显著降低，Ｇｐｓ还可减轻、甚至逆转人与犬缺氧时心输出量的减少。结果表明，Ｇｐｓ对人及大的ＨＰＶ有抑制作用。The effects of gypenosides(GPs),a saponins extracted from Gynostemma Pentaphyllum(Thunb)Makino, on systemic and pulmonary hemodynamics and hypoxic pulmonary vasoconstri-ction(HPV)were investigated in healthy men(oral dose of 180 mg GPs daily for 20 days)and in dogs(20mg/kg, iv.). There was no significant change in hemodynamica after 20-days administration of GPsin the subjects. However, HPV decreased markly from 53.14% to 14.10%, (P<0.05).A significant de-creas was also observed in platelete activation,plasma angiotension Ⅰand Ⅱ in the subjects.Aniv.injection of GPs significantiy lowered systemic and pulmonary arterial pressure, plasmamalondialdehyde content and heart rate. HPV was also reduced in dogs. Hypoxia-induced decrease of cardia output was inhibited,even reversed by GPs in men and dogs.These results showed thatGPs attenuate HPV and improve cardia function during hypoxia.

关 键 词：缺氧 肺循环 绞股蓝总皂甙 

分 类 号：R285.5[医药卫生—中药学]