聚乳酸/羟基乙酸胆总管支架在体外胆汁中的降解  

Degradation of polylactic acid/glycolic acid stents in bile in vitro

作　　者：张凯[1] 刘铜军[1] 景遐斌[2] 陈学思[2] 李建国[3] 李鹏飞[3] 

机构地区：[1]吉林大学第一医院普通外科,吉林长春130021 [2]中国科学院长春应用化学研究所,吉林长春130022 [3]吉林省榆树市医院

出　　处：《吉林大学学报（医学版）》2005年第6期909-911,共3页Journal of Jilin University：Medicine Edition

基　　金：国家自然科学基金资助课题(50373043)

摘　　要：目的:观察不同质量比聚乳酸/羟基乙酸(PLGA)胆总管支架在体外胆汁中质量、相对分子质量及外形变化的情况,找出在胆总管探查术中可替代T管作用的理想质量比的支架.方法:选用不同质量比(50/50、60/40、70/30和80/20)的PLGA可降解支架,每种比例各45只,放入装有新鲜人体胆汁的安瓶中,置于37C恒温培养箱,每日更换胆汁,隔日观测支架外形、质量和相对分子质量的变化.结果:50/50和60/40配比的支架降解高峰在9～10 d;70/30配比的支架降解高峰在13～14 d;80/20配比的支架降解高峰在17～18 d,符合临床胆总管探查术后T管拔除的时间(一般为14d).结论:80/20配比的PLGA可降解支架的降解高峰在临床T管拔除时间之后,可替代T管的作用.Objective To study the changes of different mass-ratio of polylactic acid/glycolicacid （PLGA） common bile duct stent in bile in vitro, including mass, relative molecular mass as well as physical appearance in order to find an ideal substitute for T tube in common bile duct exploration. Methods 45 stents of four different ratios （50/50, 60/40, 70/30 and 80/20） of PLGA were used respectively. All the stents were submerged into the vials with fresh human bile and incubated at 37℃. The bile was changed every day and the changes of mass, relative molecular mass and physical appearance were observed every other day. Results The degradation peak times of 50/50 and 60/40 ratio was 9-10 d, that of 70/30 stents was 13-14 d, and 80/20 ratio was 17-18 d. The degradation peak time of 80/20 ratio was consistent with the termination time （14 d） of T tube. Conclusion The degradation time of 80/20 ratio stents is consistent with the termination time of T tube, T tube can be replaced by this ratio stent.

关 键 词：生物降解 聚乳酸 羟基乙酸 支架 体外研究 

分 类 号：R657.4[医药卫生—外科学]