乌拉地尔和开搏通对低氧性肺动脉高压的急性血液动力学影响  

Acute Effects of Urapidil and Captopril on Hemodynamics in Patients with Hypoxic Pulmonary Hypertension

作　　者：凌春华[1] 蒋文平[1] 王光杰[1] 陶岳多[1] 马家用[1] 惠杰[1] 宋建平[1] 

机构地区：[1]苏州医学院附属第一医院呼吸内科

出　　处：《苏州医学院学报》1996年第2期233-235,400,共3页Acta Academiae Medicinae Suzhou

摘　　要：11例慢性阻塞性肺病合并肺动脉高压分别应用乌拉地尔和开搏通治疗。血液动力学检查结果表明:乌拉地尔降低肺动脉平均压(PAPm)0.72kPa(P<0.02),肺血管阻力(PVR)28.8%(P<0.05),体循环阻力(SVR)21.6%(P<0.01),平均提高心脏指数(CI)15.0ml·s^(-1)/m^2(P<0.02),血氧运输量(O_2—T)29%(P<0.02)。开搏通平均降低PAPm 0.34kPa(P<0.01),PVR15.6%(P<0.05),SVR 23.6%(P<0.01),平均提高CI 8.4ml·s^(-1)/m^2(P<0.05),O_2—T 2O%(P<0.02)。两组体循环血压皆正常,心率相对稳定,动脉血氧分压无明显政变。表明,在降低继发于慢性阻塞性肺病的低氧性肺动脉高压中,乌拉地尔和开搏通均可应用,且前者对肺循环的影响具有较好的特异性。The acute effects of urapidil in 5 patients and captopril in 6 patients suffering from hypoxic pulmonary hypertension in various degrees were observed. Urapidil decreased the mean pulmonary artery pressure (PAPm) by 0.72kPa, pulmonary vascular resistance (PVR) 28.8% (P<0.05),systemic vascular resistance (SVR) 21.6% (P<0.02), and increased the cardiac index (CI) 15.0 ml·s^(-1)/m^2(P<0.02) and oxygen delivery index (O_2—T) 29%(P<0.02).In contrast, captopril also can reduce the PAPm by 0.34kPa (P<0.01), PVR 15.6%(P<0.05), SVR 23.6% (P<0.01), and increased the 8.4 ml·s^(-1)/m^2(P(0.05), O_2—T 20%(P<0.02). In two groups of patients, there were no significant variation in heart rate (HR.) and arterial oxygen tension (PaO_2). The systemic blood pressure (BP) decreased slightly (P<0.05), but after administration of drug all were in normal. These results suggest that urapidil and captopril may all be used in the treatment of patients with hypoxic pulmonary hypertension. In addition, results indicate that urapidil has more effects on the pulmonary circulation than on the systemic vasculature.

关 键 词：肺动脉高压 乌拉地尔 开搏通 血液动力学 

分 类 号：R543.205[医药卫生—心血管疾病]