注射用七叶皂苷钠对热稳定性研究  

The Study of Stability of Sodium Aescinate for Injection with Heat

作　　者：陈洁[1] 赵郁[1] 杨小春[1] 刘春雨[1] 李开兰[1] 宁宁[1] 

机构地区：[1]四川大学华西医院,成都610041

出　　处：《中国药师》2005年第12期1051-1052,共2页China Pharmacist

摘　　要：目的:为临床加温使用注射用七叶皂苷钠提供稳定性实验依据。方法:按临床用药配制七叶皂苷钠-5％葡萄糖注射液混合液,考察在不同温度下放置8 h后药物的外观性状、pH值、紫外吸收图谱、含量及不溶性微粒的变化。结果:在20, 30,35,40,45℃恒温放置8 h,除含量略有下降外,其余各项指标无明显变化。结论:在20-45℃七叶皂苷钠的输液混合液在 8 h内稳定,临床可以加温使用。Objective： To offer the data of stability of sodium aescinate in injection with heat. Method： Sodium aescinate was prepared with 5% glucose injection, change of appearance, pH, UV spectrum, content, granule at different temperature were studied in 8 h. Result： The appearance,pH, UV spectrum,granule has little change, while the content decline a little at 20,30,35,40,45 ℃ in 8 h. Conclusion： The injection of sodium aescinate is stable between 20 - 45 ℃ in 8 h, and it can be clinical use with heat.

关 键 词：注射用七叶皂苷钠 热稳定性 临床应用 

分 类 号：TQ460.6[化学工程—制药化工]