Detection and evaluation of the mutations of embB gene in etham butol-susceptible and resistant Mycobacterium tuberculos isisolates from China  

作　　者：WU Xue-qiong LIANG Jian-qin ZHANG Jun-xian LU Yang LI Hong-min ZHANG Guang-yu YAN Guo-rui DING Bei-chuan 

机构地区：[1]Tuberculosis Research Laboratory, Tuberculosis Centre, 309thHospital of PLA, Beijing 100091, China [2]Clinical Laboratory, Thorax Disease Hospital of Hebei Province,Shijiazhuang 050041, China [3]Clinical Laboratory, Thorax Disease Hospital of Henan Province,Zhengzhou 450003, China [4]Clinical Laboratory, Research Institute of TB Control and Preventionof Beijing, Beijing 100035, China

出　　处：《Chinese Medical Journal》2005年第20期1739-1741,共3页中华医学杂志（英文版）

基　　金：This research was supported by the Army Research Foundation forthe Outstanding Person with Ability (No.01J020).

摘　　要：The situation of tuberculosis （TB） and Mycobacterium tuberculosis （ M. tuberculosis） drug resistance is still very serious in China. Improper treatment for TB may lead to a prolonged course of antimicrobial therapy and spreading of drug resistant strains. Thus, rapid detection of drug resistant strains will allow prompt initiation and adjustment of effective chemotherapeutic treatment of TB. Ethambutol （EMB） is a first line anti-TB drug. embB Met306 is located in a cytoplasmic loop that forms an EMB resistance determining region,The situation of tuberculosis （TB） and Mycobacterium tuberculosis （ M. tuberculosis） drug resistance is still very serious in China. Improper treatment for TB may lead to a prolonged course of antimicrobial therapy and spreading of drug resistant strains. Thus, rapid detection of drug resistant strains will allow prompt initiation and adjustment of effective chemotherapeutic treatment of TB. Ethambutol （EMB） is a first line anti-TB drug. embB Met306 is located in a cytoplasmic loop that forms an EMB resistance determining region,

关 键 词：drug resistance ETHAMBUTOL polymerase chain reaction polymorphism single-stranded conformational Mycobacterium tuberculosis 

分 类 号：R521[医药卫生—内科学] R978.3[医药卫生—临床医学]